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Wound healing of diabetic rats treated with Moringa oleifera extract
Azevedo, Ítalo Medeiros; Araújo-Filho, Irami; Teixeira, Marianny Maiara Antas; Moreira, Marília Daniela Ferreira de Carvalho; Medeiros, Aldo Cunha.
  • Azevedo, Ítalo Medeiros; Universidade Federal do Rio Grande do Norte. Postgraduate Program in Health Sciences. Natal. BR
  • Araújo-Filho, Irami; UFRN. Department of Surgery. Natal. BR
  • Teixeira, Marianny Maiara Antas; UFRN. Natal. BR
  • Moreira, Marília Daniela Ferreira de Carvalho; UFRN. Hospital Universitário Onofre Lopes. Natal. BR
  • Medeiros, Aldo Cunha; UFRN. Nucleus of Experimental Surgery. Natal. BR
Acta cir. bras ; 33(9): 799-805, Sept. 2018. tab
Article in English | LILACS | ID: biblio-973496
ABSTRACT
Abstract

Purpose:

To evaluate if Moringa oleifera leaf aqueous extract (ME) influences the healing of skin wounds of diabetic rats.

Methods:

Wistar rats were used (6 rats/group). Group 1 received normal saline (NS) v.o. Group 2 received moringa extract (100mg/kg v.o) for 3 weeks. Groups 3 and 4 Streptozotocin (STZ) induced diabetes. Group 3 received NS; Group 4 received aqueous ME (100mg/kg) v.o.The wounds of groups 1 and 3 rats were topically treated with NS; wounds of groups 2 and 4 treated with 200µL of 10% ME. After anesthesia, all rats had skin square excision wounds 1.5cm2. Wound percent contractions were measured. On 10th day, blood glucose and serum cytokines were measured. Histometry of wounds was studied using ImagePro6.0 software.

Results:

Glycemia was significantly reduced in ME treated rats. These rats had higher percent contraction of the wounds on 2nd, 5th and 10th days, then controls (p<0.05). Diabetic rats treated with NS had TNF-α, IL-1β and IL-6 expression higher than in rats receiving ME. The histopathological score of ME treated diabetic rats (198±13.7) was significantly higher than treatment with NS (145±10.5).

Conclusion:

ME extract positively influenced healing of wounds in diabetic rats after systemic and topical treatment.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Wound Healing / Plant Extracts / Moringa oleifera Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFRN/BR / Universidade Federal do Rio Grande do Norte/BR

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Full text: Available Index: LILACS (Americas) Main subject: Wound Healing / Plant Extracts / Moringa oleifera Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFRN/BR / Universidade Federal do Rio Grande do Norte/BR