Role of moxifloxacin-dexamethasone in cardiac histomorphometric findings among Wistar rats from infected mothers
Acta cir. bras
;
33(9): 744-752, Sept. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-973504
ABSTRACT
Abstract Purpose:
To investigate cardiac changes in young rats, whose mothers underwent autogenic fecal peritonitis, during organogenesis phase and to evaluate the role of intravenous administration of moxifloxacin and dexamethasone in preventing infection-related cardiac changes.Methods:
A prospective histomorphometric study was performed on 29 hearts of Wistar four-month old rats. Animals were divided into three groups Negative Control Group (NCG) included 9 subjects from healthy mothers; Positive Control Group (PCG) included 10 subjects from mothers with fecal peritonitis (intra-abdominal injection of 10% autogenic fecal suspension in the gestational period) and did not receive any treatment; and Intervention Group (IG), with 10 animals whose infected mothers received moxifloxacin and dexamethasone treatment 24 hours after induction of fecal peritonitis.Results:
Nuclear count was higher in the IG group as compared to PCG (p = 0.0016) and in NCG as compared to PCG (p = 0.0380). There was no significant difference in nuclear counts between NCG and IG.Conclusion:
Induced autogenic fecal peritonitis in pregnant Wistar rats determined myocardial changes in young rats that could be avoided by the early administration of intravenous moxifloxacin and dexamethasone.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Peritonitis
/
Dexamethasone
/
Fluoroquinolones
/
Myocardium
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Limits:
Animals
/
Pregnancy
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UFPE/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Federal de Pernambuco/BR
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