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Multiple sclerosis: disease modifying therapy and the human leukocyte antigen / Esclerose múltipla: terapêutica modificadora da doença e antígenos leucocitários humanos
Werneck, Lineu Cesar; Lorenzoni, Paulo José; Kay, Cláudia Suemi Kamoi; Scola, Rosana Herminia.
  • Werneck, Lineu Cesar; Universidade Federal do Paraná. Hospital de Clínicas. Serviço de Neurologia. Curitiba. BR
  • Lorenzoni, Paulo José; Universidade Federal do Paraná. Hospital de Clínicas. Serviço de Neurologia. Curitiba. BR
  • Kay, Cláudia Suemi Kamoi; Universidade Federal do Paraná. Hospital de Clínicas. Serviço de Neurologia. Curitiba. BR
  • Scola, Rosana Herminia; Universidade Federal do Paraná. Hospital de Clínicas. Serviço de Neurologia. Curitiba. BR
Arq. neuropsiquiatr ; 76(10): 697-704, Oct. 2018. tab
Article in English | LILACS | ID: biblio-973921
ABSTRACT
ABSTRACT

Objective:

To investigate the potential relationship between the human leukocyte antigen (HLA) type (class I and II) and the response to several disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS).

Methods:

We analyzed clinical data of 87 patients with MS at the beginning and end of each type of DMT including the disease duration, Expanded Disability Status Scale and Multiple Sclerosis Severity Score (MSSS). Genotyping of HLA-DRB1, HLA-DPB1, HLA-DQB1, HLA-A, HLA-B and HLA-C alleles were identified using high-resolution techniques. Statistical correlation between the HLA type and response to DMTs was done using the initial and final MSSS.

Results:

Statistical relationships (p < 0.05) were found for only 15 of 245 alleles tested. There was a reduction in the MSSS for patients treated with corticosteroids (DRB1*1501, DPB1*0401, DQB1*0201 and DQB1*0301), azathioprine (DRB1*0301, DPB1*0401, DQB1*0302, DQB1*0602, HLA-C*0702), interferon β-1a 22 mcg (DRB1*1104, DQB1*0301 and DQB1*0302), interferon β-1a 30 mcg (DPB1*0201, HLA-C*0501) and interferon β-1b (DQB1*0201).

Conclusion:

These findings suggest a few relationships between the HLA and response to DMTs in the disability for some types of HLA class I and II alleles in a specific subset of MS patients.
RESUMO
RESUMO

Objetivo:

Investigação da possível relação entre os tipos dos antígenos leucocitários humanos (HLA) classes I e II e a reposta a diversas terapêuticas modificadores da doença na incapacidade (DMT) da esclerose múltipla (MS).

Métodos:

Foram estudados os dados clínicos de 87 pacientes com MS no início e no final de cada de cada DMT, incluindo o tempo de doença, EDSS e MSSS. Através de técnicas de genotipagem de alta resolução, foram identificados os alelos dos HLA-DRB1, HLA-DPB1, HLA-DQB1, HLA-A, HLA-B e HLA-C. Foram realizados estudos estatísticos entre os tipos de HLA e a resposta às DMT, utilizando os valores iniciais e finais do MSSS.

Resultados:

Foram encontradas relações estatísticas (p < 0.05) para somente 15 alelos de 245 analisados. Houve redução dos valores do MSSS em pacientes tratados com corticosteroides (DRB1*1501, DPB1*0401, DQB1*0201 e 0301), azatioprina (DRB1*0301, DPB1*0401, DQB1*0602, DQB1*0302, HLA-C*0702), interferon β-1a 22 mcg (DRB1*1104, DQB1*0301 e 0302), interferon β-1a 30 mcg (DPB1*0201, HLA-C*0501) e interferon β-1b (DQB1*0201).

Conclusão:

Os dados sugerem poucas relações entre os alguns tipos de HLA classe I e II com a resposta às DMT na incapacidade em grupos específicos de pacientes com MS.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Multiple Sclerosis, Relapsing-Remitting / HLA Antigens Type of study: Prognostic study Limits: Adolescent / Adult / Child / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Multiple Sclerosis, Relapsing-Remitting / HLA Antigens Type of study: Prognostic study Limits: Adolescent / Adult / Child / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Paraná/BR