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Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism
Rech, Tássia Flores; Mazzoleni, Luiz Edmundo; Mazzoleni, Felipe; Francesconi, Carlos Fernando de Magalhães; Sander, Guilherme Becker; Michita, Rafael Tomoya; Nabinger, Débora Dreher; Milbradt, Tobias Cancian; Torresini, Ronaldo João Spinato; Simon, Daniel.
  • Rech, Tássia Flores; Universidade Luterana do Brasil. Laboratório de Genética Molecular Humana. Canoas. BR
  • Mazzoleni, Luiz Edmundo; Hospital de Clínicas de Porto Alegre. Serviço de Gastroenterologia. Porto Alegre. BR
  • Mazzoleni, Felipe; Hospital de Clínicas de Porto Alegre. Serviço de Gastroenterologia. Porto Alegre. BR
  • Francesconi, Carlos Fernando de Magalhães; Hospital de Clínicas de Porto Alegre. Serviço de Gastroenterologia. Porto Alegre. BR
  • Sander, Guilherme Becker; Hospital de Clínicas de Porto Alegre. Serviço de Gastroenterologia. Porto Alegre. BR
  • Michita, Rafael Tomoya; Universidade Luterana do Brasil. Laboratório de Genética Molecular Humana. Canoas. BR
  • Nabinger, Débora Dreher; Universidade Luterana do Brasil. Laboratório de Genética Molecular Humana. Canoas. BR
  • Milbradt, Tobias Cancian; Hospital de Clínicas de Porto Alegre. Serviço de Gastroenterologia. Porto Alegre. BR
  • Torresini, Ronaldo João Spinato; Hospital de Clínicas de Porto Alegre. Serviço de Gastroenterologia. Porto Alegre. BR
  • Simon, Daniel; Universidade Luterana do Brasil. Laboratório de Genética Molecular Humana. Canoas. BR
Braz. j. infect. dis ; 22(4): 311-316, July-Aug. 2018. tab, graf
Article in English | LILACS | ID: biblio-974231
ABSTRACT
ABSTRACT Aim To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia. Methods Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism. Results One hundred forty-nine patients received treatment with triple therapy for H. pylori eradication. Only one patient was lost to follow-up, and adherence to study medication was 94.6%. A total of 148 patients (mean age 46.08 ± 12.24 years; 81.8% women) were evaluated for the influence of the interleukin-1beta -31 C/T polymorphism on the outcome of H. pylori eradication therapy. After treatment, bacteria were eradicated in 87% of patients (129/148). Genotype frequencies of the polymorphism were as follows CC, 38/148 (25.7%); CT, 71/148 (47.9%); and TT, 39/148 (26.4%). Successful eradication rate was 78.9%, 94.4% and 82.1% for the CC, CT and TT genotypes, respectively. The CT genotype was significantly associated with successful H. pylori eradication (p= 0.039). Conclusion This study suggests that the CT genotype of the interleukin-1beta -31 C/T polymorphism plays a role in the successful eradication of H. pylori among patients with functional dyspepsia.
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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Helicobacter pylori / Helicobacter Infections / Dyspepsia / Interleukin-1beta / Anti-Bacterial Agents Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital de Clínicas de Porto Alegre/BR / Universidade Luterana do Brasil/BR

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Helicobacter pylori / Helicobacter Infections / Dyspepsia / Interleukin-1beta / Anti-Bacterial Agents Type of study: Controlled clinical trial / Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital de Clínicas de Porto Alegre/BR / Universidade Luterana do Brasil/BR