The rs878081 polymorphism of AIRE gene increases the risk of rheumatoid arthritis in a Chinese Han population: a case-control study
Braz. j. med. biol. res
;
51(12): e7944, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-974256
ABSTRACT
The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid arthritis (RA) in different populations have yielded conflicting findings. Thus, this case-control study involving 300 RA cases and 300 controls was aimed to identify whether such association existed in a Chinese Han population from East China. The rs878081 polymorphism of the AIRE gene was genotyped. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using the chi-squared test, genetic model analysis, and stratification analysis. Genetic model analysis showed significant correlations between the TT genotype and the risk of RA (OR 1.89, 95%CI 1.03-3.47 in TT vs CC; OR 1.84, 95%CI 1.02-3.31 in TT vs CC+TC). Stratification analyses of sex, age, smoking, and alcoholism suggested that the rs878081 polymorphism of the AIRE gene increased RA risk among non-smokers. In conclusion, rs878081 polymorphism of AIRE gene increases the risk of RA in a Chinese Han population.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Arthritis, Rheumatoid
/
Transcription Factors
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University/CN
/
Second Affiliated Hospital of Jiaxing University/CN
/
Second Affiliated Hospital, Zhejiang University School of Medicine/CN
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