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Appraisal of acute oral toxicity of glucuronoxylan hydrogel from Mimosa pudica seeds
Muhammad, Gulzar; Hussain*, Muhammad Ajaz; Ashraf, Muhammad Umer; Naeem-ul-Hassan, Muhammad; Bukhari, Syed Nasir Abbas.
  • Muhammad, Gulzar; GC University Lahore. Department of Chemistry. PK
  • Hussain*, Muhammad Ajaz; University of Sargodha. Department of Chemistry. Sargodha. PK
  • Ashraf, Muhammad Umer; University of Sargodha. Faculty of Pharmacy. Sargodha. PK
  • Naeem-ul-Hassan, Muhammad; University of Sargodh. Department of Chemistry. Sargodha. PK
  • Bukhari, Syed Nasir Abbas; Jouf University. Department of Pharmaceutical Chemistry. College of Pharmacy. Aljouf. SA
Braz. J. Pharm. Sci. (Online) ; 54(3): e17579, 2018. tab, graf
Article in English | LILACS | ID: biblio-974398
ABSTRACT
Glucuronoxylan hydrogel (GXH) isolated from M. pudica seeds was assessed for acute toxicology in albino mice that were alienated into four groups. Three groups, i.e., II, III and IV received GXH at a dose of 1, 2 and 5 g/kg, respectively while group I was retained untreated and provided routine diet. After administering GXH, mice were examined for vomiting, diarrhea, allergy and tremors for 8 h. All animals were carefully observed for food and water consumption at 1, 2, 3, 7 and 14 day after administering GXH. At the end of studies, blood samples were drawn for investigation of hematological and biochemical parameters. All animals were sacrificed, relative body weight of vital organs was calculated and their histopathology was studied. It was concluded that there was insignificant difference in body weight, behavioral pattern, food and water intake among treated and control groups. Haematology and biochemistry of blood samples from all groups were found analogous. Histopathological evaluation of vital body organs exhibited no lesions in all groups. Ocular, cardiac and dermal safety of GXH was also established on albino rabbits.
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Full text: Available Index: LILACS (Americas) Main subject: Mimosa pudica / Hydrogels / Toxicity Tests, Acute Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Pakistan / Saudi Arabia Institution/Affiliation country: GC University Lahore/PK / Jouf University/SA / University of Sargodh/PK / University of Sargodha/PK

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Full text: Available Index: LILACS (Americas) Main subject: Mimosa pudica / Hydrogels / Toxicity Tests, Acute Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Pakistan / Saudi Arabia Institution/Affiliation country: GC University Lahore/PK / Jouf University/SA / University of Sargodh/PK / University of Sargodha/PK