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Drug discovery and computational strategies in the multitarget drugs era
Viana, Jéssika de Oliveira; Félix, Mayara Barbalho; Maia, Mayara dos Santos; Serafim, Vanessa de Lima; Scotti, Luciana; Scotti, Marcus Tullius.
  • Viana, Jéssika de Oliveira; Federal University of Paraíba. Program of Natural and Synthetic Bioactive Products. Health Sciences Center. João Pessoa. BR
  • Félix, Mayara Barbalho; Federal University of Paraíba. Program of Natural and Synthetic Bioactive Products. Health Sciences Center. João Pessoa. BR
  • Maia, Mayara dos Santos; Federal University of Paraíba. Program of Natural and Synthetic Bioactive Products. Health Sciences Center. João Pessoa. BR
  • Serafim, Vanessa de Lima; Federal University of Paraíba. Program of Natural and Synthetic Bioactive Products. Health Sciences Center. João Pessoa. BR
  • Scotti, Luciana; Federal University of Paraíba. Program of Natural and Synthetic Bioactive Products. Health Sciences Center. João Pessoa. BR
  • Scotti, Marcus Tullius; Federal University of Paraíba. Program of Natural and Synthetic Bioactive Products. Health Sciences Center. João Pessoa. BR
Braz. J. Pharm. Sci. (Online) ; 54(spe): e01010, 2018. tab, graf
Article in English | LILACS | ID: biblio-974423
ABSTRACT
The pharmaceutical industry is increasingly joining chemoinformatics in the search for the development of new drugs to be used in the treatment of diseases. These computational studies have the advantage of being less expensive and optimize the study time, and thus the interest in this area is increasing. Among the techniques used is the development of multitarget directed ligands (MTDLs), which has become an ascending technique, mainly due to the improvement in the quality of treatment involving several drugs. Multitarget therapy is more effective than traditional drug therapy that emphasizes maximum selectivity for a single target. In this review a multitarget drug survey was carried out as a promising strategy in several important diseases neglected diseases, neurodegenerative diseases, AIDS, and cancer. In addition, we discuss Computer-Aided Drug Design (CADD) techniques as a tool in the projection of multitarget compounds against these diseases.
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Full text: Available Index: LILACS (Americas) Main subject: Computer Simulation / Drug Design Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraíba/BR

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Full text: Available Index: LILACS (Americas) Main subject: Computer Simulation / Drug Design Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraíba/BR