miR-141 is up-regulated in biopsies from Vietnamese patients with nasopharyngeal carcinoma
Braz. oral res. (Online)
;
32: e126, 2018. graf
Article
in English
| LILACS
| ID: biblio-974437
ABSTRACT
Abstract Novel biomarkers for screening, diagnosis and monitoring the treatment of nasopharyngeal carcinoma (NPC), one of the most common cancers in Vietnam, are urgently required. Increasing evidence suggests that microRNA-141 (miR-141) is associated with NPC, owing to its ability to affect the expression of genes that modulate tumorigenesis. Unfortunately, research on miR-141 expression in Vietnamese patients is limited. Therefore, the objective of the current study was to evaluate miR-141 expression and assess whether miR-141 might be a potential biomarker for diagnosis of NPC in Vietnamese patients. Total RNA isolated from 40 NPC biopsy samples and 37 non-cancerous samples was analyzed by quantitative reverse-transcription PCR. The miR-141 expression levels were compared between NPC biopsy and non-cancerous samples. The frequency of miR-141 detection was 37.50% and 10.80% in the NPC and non-cancerous samples, respectively (p = 0.0143). The miR-141 expression was 5.27 times higher in tumor samples than non-cancerous samples. Additionally, the RR (Relative risk) and OR (Odds ratio) were 1.83 (95%CI = 1.2576-2.6675, p = 0.0016) and 4.95 (95%CI = 1.4625-16.7541, p = 0.01), respectively. In conclusion, miR-141 was up-regulated in the biopsy samples and thus may be a potential biomarker for NPC in the Vietnamese population.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Nasopharyngeal Neoplasms
/
MicroRNAs
/
Nasopharyngeal Carcinoma
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Braz. oral res. (Online)
Journal subject:
Dentistry
Year:
2018
Type:
Article
Affiliation country:
Vietnam
Institution/Affiliation country:
Cho Ray Hospital/VN
/
Ho Chi Minh City International University/VN
/
Ho Chi Minh City Open University/VN
/
University of Science/VN
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