Dendritic cells and their relation to apical peridontitis
Braz. oral res. (Online)
;
32(supl.1): e71, 2018. graf
Article
in English
| LILACS
| ID: biblio-974472
ABSTRACT
Abstract The purpose of this manuscript was to re-discuss apical periodontitis, apical biofilm, and its possible relationship with dendritic cells (DC). DCs are potent regulators of the immune system and their function is divided into three categories that involve the presentation of antigens the presentation of antigens and activation of T cells; a not well established category suggested that DCs induce and maintain immunological tolerance; and the maintenance of the immune memory in conjunction with B cells. DCs in periapical inflammatory lesions are composed of at least two subpopulations that can be distinguished on the basis of ultrastructure and phenotype. These populations might differ in lineage, state of maturation, differentiation, activation, and/or function. The authors hereby analyzed the root apexes of teeth under SEM, after performing apicoectomy due to the failure of conventional endodontic treatment. Microbial biofilm with multispecies and areas of resorption with the presence of Howship lacunae, and images suggestive of denditric cells could be observed. The presence of DCs in periapical lesion could be an indication of the severity of the lesion, with a constant presence of antigen in the periradicular region.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Periapical Periodontitis
/
Dendritic Cells
/
Biofilms
Limits:
Humans
Language:
English
Journal:
Braz. oral res. (Online)
Journal subject:
Dentistry
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS/BR
/
Universidade Federal do Rio Grande do Sul - UFRGS/BR
/
Universidade Luterana do Brasil - ULBRA/BR
/
Universidade de Cuiabá - UNIC/BR
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