Relationships of interleukin-10 with the regulatory T cell ratio and prognosis of cervical cancer patients
Clinics
;
73: e679, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-974917
ABSTRACT
OBJECTIVE:
This study investigated serum interleukin-10 (IL-10) levels, changes in peripheral blood CD4+CD25+ regulatory T cell (PBCDT) ratios, and the prognosis of cervical cancer (CC) patients.METHODS:
Seventy patients with CC composed the observation group, and 70 healthy subjects composed the control group. The PBCDT ratios in the CC patients and healthy subjects were calculated. Serum IL-10 levels were detected with a double antibody sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS:
The PBCDT ratio was higher in the patients with active CC [12.16±2.41%] than in the control subjects [6.34±1.05%]. Serum IL-10 levels were higher in the patients with CC [384±106 pg/ml] than in the control subjects [104±50 pg/ml]; the differences in both PBCDT ratio and IL-10 level were statistically significant (p<0.01). Serum IL-10 levels were positively correlated with PBCDT ratios (r=0.375, p<0.05). The 5-year patient survival rate was significantly higher in the low serum IL-10 group (64.2%) than in the high serum IL-10 group (42.8%, p=0.012).CONCLUSIONS:
PBCDT ratios and serum IL-10 levels are related to CC activity. These factors are reciprocally related and influence one another, and both are involved in the development and progression of CC. Low IL-10 expression is beneficial regarding the survival of patients with CC.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Antigens, CD
/
Uterine Cervical Neoplasms
/
Interleukin-10
/
T-Lymphocytes, Regulatory
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Shanghai Jiao Tong University/CN
/
the First Affiliated Hospital of Bengbu Medical College/CN
/
the Third People's Hospital of Bengbu/CN
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