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Relationships of interleukin-10 with the regulatory T cell ratio and prognosis of cervical cancer patients
Wang, Beibei; Wang, Haoyu; Li, Peiquan; Wang, Liangliang; Liu, Hongli; Liu, Jingbo; Wang, Lihua.
  • Wang, Beibei; the First Affiliated Hospital of Bengbu Medical College. Department of gynecologic oncology. CN
  • Wang, Haoyu; the Third People's Hospital of Bengbu. Department of orthopaedics. CN
  • Li, Peiquan; Shanghai Jiao Tong University. Renji Affiliated Hospital. Department of gynecologic oncology. Shanghai. CN
  • Wang, Liangliang; the First Affiliated Hospital of Bengbu Medical College. Department of gynecologic oncology. CN
  • Liu, Hongli; the First Affiliated Hospital of Bengbu Medical College. Department of gynecologic oncology. CN
  • Liu, Jingbo; the First Affiliated Hospital of Bengbu Medical College. Department of gynecologic oncology. CN
  • Wang, Lihua; the First Affiliated Hospital of Bengbu Medical College. Department of gynecologic oncology. CN
Clinics ; 73: e679, 2018. tab, graf
Article in English | LILACS | ID: biblio-974917
ABSTRACT

OBJECTIVE:

This study investigated serum interleukin-10 (IL-10) levels, changes in peripheral blood CD4+CD25+ regulatory T cell (PBCDT) ratios, and the prognosis of cervical cancer (CC) patients.

METHODS:

Seventy patients with CC composed the observation group, and 70 healthy subjects composed the control group. The PBCDT ratios in the CC patients and healthy subjects were calculated. Serum IL-10 levels were detected with a double antibody sandwich enzyme-linked immunosorbent assay (ELISA).

RESULTS:

The PBCDT ratio was higher in the patients with active CC [12.16±2.41%] than in the control subjects [6.34±1.05%]. Serum IL-10 levels were higher in the patients with CC [384±106 pg/ml] than in the control subjects [104±50 pg/ml]; the differences in both PBCDT ratio and IL-10 level were statistically significant (p<0.01). Serum IL-10 levels were positively correlated with PBCDT ratios (r=0.375, p<0.05). The 5-year patient survival rate was significantly higher in the low serum IL-10 group (64.2%) than in the high serum IL-10 group (42.8%, p=0.012).

CONCLUSIONS:

PBCDT ratios and serum IL-10 levels are related to CC activity. These factors are reciprocally related and influence one another, and both are involved in the development and progression of CC. Low IL-10 expression is beneficial regarding the survival of patients with CC.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Antigens, CD / Uterine Cervical Neoplasms / Interleukin-10 / T-Lymphocytes, Regulatory Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Shanghai Jiao Tong University/CN / the First Affiliated Hospital of Bengbu Medical College/CN / the Third People's Hospital of Bengbu/CN

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Full text: Available Index: LILACS (Americas) Main subject: Antigens, CD / Uterine Cervical Neoplasms / Interleukin-10 / T-Lymphocytes, Regulatory Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2018 Type: Article Affiliation country: China Institution/Affiliation country: Shanghai Jiao Tong University/CN / the First Affiliated Hospital of Bengbu Medical College/CN / the Third People's Hospital of Bengbu/CN