Impact of 68GA-PSMA PET / CT on treatment of patients with recurrent / metastatic high risk prostate cancer - a multicenter study
Int. braz. j. urol
;
44(5): 892-899, Sept.-Oct. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-975631
ABSTRACT
ABSTRACT Purpose:
The purpose of our study was to evaluate the clinical impact of 68Ga-PSMA PET / CT in the setting of biochemical recurrence of prostate cancer. Materials andMethods:
We retrospectively evaluated 125 prostate cancer patients submitted to the 68Ga-PSMA PET / CT due to biochemical recurrence. The parameters age, Gleason score, PSA levels, and the highest SUVmax were correlated to potential treatment changes. The highest SUVmax values were correlated with age and Gleason score. The median follow-up time was 24 months.Results:
68Ga-PSMA PET / CT led to a treatment change in 66 / 104 (63.4%) patients (twenty-one patients were lost to follow-up). There was a significant change of treatment plan in patients with a higher Gleason score (P = 0.0233), higher SUVmax (p = 0.0306) and higher PSA levels (P < 0.0001; median PSA = 2.55 ng / mL).Conclusion:
68Ga-PSMA PET / CT in prostate cancer patients with biochemical recurrence has a high impact in patient management.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Oligopeptides
/
Prostatic Neoplasms
/
Edetic Acid
/
Prostate-Specific Antigen
/
Positron Emission Tomography Computed Tomography
/
Neoplasm Recurrence, Local
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro de Oncologia de D'Or/BR
/
Grupo Américas Centro de Oncologia Integrado/BR
/
Hospital Sírio - Libanês/BR
/
Universidade Estadual de Campinas/BR
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