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BK virus salivary shedding and viremia in renal transplant recipients
Stomatology DepartmentSarmento, Dmitry José de Santana; Stomatology DepartmentPalmieri, Michelle; Stomatology DepartmentGalvão, Gustavo Souza; Laboratory of VirologyTozetto-Mendoza, Tânia Regina; Laboratory of VirologyCanto, Cynthia Motta do; Hospital das ClínicasPierrotti, Ligia Camera; Hospital das ClínicasDavid-Neto, Elias; Hospital das ClínicasAgena, Fabiana; Stomatology DepartmentGallottini, Marina; Laboratory of VirologyPannuti, Claudio Sergio; Laboratory of VirologyFink, Maria Cristina Domingues; Stomatology DepartmentBraz-Silva, Paulo Henrique.
  • Stomatology DepartmentSarmento, Dmitry José de Santana; University of São Paulo. School of Dentistry. Stomatology DepartmentSarmento, Dmitry José de Santana. São Paulo. BR
  • Stomatology DepartmentPalmieri, Michelle; University of São Paulo. School of Dentistry. Stomatology DepartmentPalmieri, Michelle. São Paulo. BR
  • Stomatology DepartmentGalvão, Gustavo Souza; University of São Paulo. School of Dentistry. Stomatology DepartmentGalvão, Gustavo Souza. São Paulo. BR
  • Laboratory of VirologyTozetto-Mendoza, Tânia Regina; University of São Paulo. Institute of Tropical Medicine of São Paulo. Laboratory of VirologyTozetto-Mendoza, Tânia Regina. São Paulo. BR
  • Laboratory of VirologyCanto, Cynthia Motta do; University of São Paulo. Institute of Tropical Medicine of São Paulo. Laboratory of VirologyCanto, Cynthia Motta do. São Paulo. BR
  • Hospital das ClínicasPierrotti, Ligia Camera; University of São Paulo. Medical School. Hospital das ClínicasPierrotti, Ligia Camera. São Paulo. BR
  • Hospital das ClínicasDavid-Neto, Elias; University of São Paulo. Medical School. Hospital das ClínicasDavid-Neto, Elias. São Paulo. BR
  • Hospital das ClínicasAgena, Fabiana; University of São Paulo. Medical School. Hospital das ClínicasAgena, Fabiana. São Paulo. BR
  • Stomatology DepartmentGallottini, Marina; University of São Paulo. School of Dentistry. Stomatology DepartmentGallottini, Marina. São Paulo. BR
  • Laboratory of VirologyPannuti, Claudio Sergio; University of São Paulo. Institute of Tropical Medicine of São Paulo. Laboratory of VirologyPannuti, Claudio Sergio. São Paulo. BR
  • Laboratory of VirologyFink, Maria Cristina Domingues; University of São Paulo. Institute of Tropical Medicine of São Paulo. Laboratory of VirologyFink, Maria Cristina Domingues. São Paulo. BR
  • Stomatology DepartmentBraz-Silva, Paulo Henrique; University of São Paulo. School of Dentistry. Stomatology DepartmentBraz-Silva, Paulo Henrique. São Paulo. BR
J. appl. oral sci ; 27: e20180435, 2019. tab
Article in English | LILACS, BBO | ID: biblio-975897
ABSTRACT
Abstract

Objectives:

This study aimed to verify the presence of polyomavirus BK (BKPyV) in the saliva of kidney transplant recipients and to correlate it with blood viremia. Material and

Methods:

We have conducted a cross-sectional study with a sample involving 126 renal transplant recipients. 126 samples of saliva and 52 samples of blood were collected from these patients. Detection and quantification of BKPyV were performed using a real-time PCR. To compare the presence of BKPyV in blood and saliva, the binomial proportion test was used. To verify associations between salivary shedding BKPyV and post-transplant periods (in months), the Mann-Whitney test was used. Spearman's correlation was used to correlate the viral load in the saliva with blood of kidney transplant recipients.

Results:

The mean age of the study group was 51.11±12.45 years old, and 69 participants (54.8%) were female, with a mean post-transplantation time of 4.80±6.04 months. BKPyV was quantified in several samples of saliva and blood, with medians of 1,108 cp/mL and 1,255 cp/mL, respectively. Only 16/52 (30.8%) participants presented BKPyV in blood, and 59/126 (46.8%) excreted the virus in saliva (p=0.004). BKPyV shedding was found in patients at a shorter post-transplantation period (3.86±5.25, p=0.100). A weak correlation was observed between viral quantification in saliva and blood (Spearman's correlation coefficient=0.193).

Conclusion:

The results of this study suggested that, although saliva excretes more BKPyV than blood, there is no reliable correlation between salivary shedding and blood viremia, showing two independent compartments of viral replication.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Saliva / Viremia / Kidney Transplantation / Virus Shedding / BK Virus / Transplant Recipients Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Saliva / Viremia / Kidney Transplantation / Virus Shedding / BK Virus / Transplant Recipients Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR