Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review
Rev. Soc. Bras. Med. Trop
;
51(6): 725-730, Nov.-Dec. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-977100
ABSTRACT
Abstract Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual's susceptibility to invasive aspergillosis. We investigated the pertinent literature to determine whether polymorphisms in the genes encoding toll-like receptors and dectin-1 increase the susceptibility to invasive aspergillosis. This study systematically reviewed the literature using the databases PubMed/PMC, Scopus, and Web of Science using the keywords invasive aspergillosis, polymorphism, Toll-like, and Dectin-1. From the initial search, 415 studies were found and according to our inclusion and exclusion criteria, eight studies were selected. Several studies described single-nucleotide polymorphisms (SNPs) that are associated with a greater susceptibility to invasive aspergillosis. These SNPs were found in the genes that encode toll-like receptors 1, 3, 4, and 5 and the gene that encodes dectin-1; upon activation, both cellular receptors initiate a signaling cascade that can result in the production of cytokines and chemokines. Thus, our literature review uncovered a significant association between polymorphisms in the genes that encode toll-like receptors and dectin-1 and invasive aspergillosis. More studies should be performed to better understand the relationship between toll-like receptor and dectin-1 genetic polymorphisms and invasive aspergillosis susceptibility.
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Index:
LILACS (Americas)
Main subject:
Aspergillosis
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Lectins, C-Type
/
Toll-Like Receptors
Type of study:
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Associação de Combate ao Câncer de Goiás/BR
/
Instituto Federal de Educação Ciência e Tecnologia do Estado de Goiás/BR
/
Pontifícia Universidade Católica de Goiás/BR
/
Universidade Federal de Goiás/BR
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