Your browser doesn't support javascript.
loading
Influence of the inflammatory response on treatment of hepatitis C with triple therapy
Winckler, Fernanda Cristina; Braz, Aline Marcia Marques; Silva, Vanessa Nogueira da; Golim, Marjorie de Assis; Andrade, Vanessa Gutierrez de; Machado, Paulo Eduardo de Abreu; Silveira, Liciana Vaz de Arruda; Silva, Giovanni Faria.
  • Winckler, Fernanda Cristina; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
  • Braz, Aline Marcia Marques; Universidade Estadual Paulista. Hemocentro. Laboratório de Citometria de Fluxo. Botucatu. BR
  • Silva, Vanessa Nogueira da; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
  • Golim, Marjorie de Assis; Universidade Estadual Paulista. Hemocentro. Laboratório de Citometria de Fluxo. Botucatu. BR
  • Andrade, Vanessa Gutierrez de; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
  • Machado, Paulo Eduardo de Abreu; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
  • Silveira, Liciana Vaz de Arruda; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Bioestatística. Botucatu. BR
  • Silva, Giovanni Faria; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
Rev. Soc. Bras. Med. Trop ; 51(6): 731-736, Nov.-Dec. 2018. tab
Article in English | LILACS | ID: biblio-977101
ABSTRACT
Abstract

INTRODUCTION:

Chronic hepatitis C is a leading cause of liver disease. Infection triggers an immediate immune response in the host that is mediated by humoral/cellular mechanisms. T cells respond to infection via secretion of cytokines, which inhibit or stimulate one another, leading to cytokine imbalance and ultimately affecting treatment. Studies using interferon (IFN) and ribavirin (RBV) showed that TCD8+ cells and cytokine levels are associated with sustainable virological response (SVR). However, studies that investigated the effects of triple therapy (TT) are limited.

METHODS:

The study included hepatitis C virus (HCV)+ RNA, naives, genotype 1, ≥18 years, and advanced fibrosis (F≥3) patients. Samples were collected at baseline and after 12 weeks (W12) of TT. Six cytokines were analyzed by flow cytometry.

RESULTS:

Of 31 patients, four were excluded (two deaths, one interrupted TT, and one F2 patient). Of the 27 remaining patients, 21 (78%) were cirrhotic. SVR was achieved in 63% of the patients. The patients had a mean age of 55.11 ± 10.03 years. Analyses at baseline showed that the chemokine CCL5/Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) (p=0.04) and interleukin (IL)-6 (p=0.02), which was associated with SVR. RANTES (p=0.04) and IL-8 (p=0.01) levels were associated with SVR at W12. CONCLUSIONS Similar to patterns observed during double therapy, IL-6, IL-8, and RANTES levels were associated with SVR in TT, indicating the potential role of interferon in immune response to hepatitis C virus.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Oligopeptides / Proline / Cytokines / Hepatitis C, Chronic Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Antiviral Agents / Oligopeptides / Proline / Cytokines / Hepatitis C, Chronic Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR