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Fluctuations in serological hepatitis C virus levels in HIV patients
Silva, Vanessa Cristina Martins; Calux, Samira Julien; Lemos, Marcilio Figueiredo; Compri, Adriana Parise; Santos, Ana Paula de Torres; Oba, Isabel Takano; Mendes-Correa, Maria Cássia Jacintho; Moreira, Regina Célia.
  • Silva, Vanessa Cristina Martins; Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites Virais. São Paulo. BR
  • Calux, Samira Julien; Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites Virais. São Paulo. BR
  • Lemos, Marcilio Figueiredo; Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites Virais. São Paulo. BR
  • Compri, Adriana Parise; Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites Virais. São Paulo. BR
  • Santos, Ana Paula de Torres; Universidade de São Paulo. Hospital das Clínicas. Laboratório de Imunologia. São Paulo. BR
  • Oba, Isabel Takano; Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites Virais. São Paulo. BR
  • Mendes-Correa, Maria Cássia Jacintho; Universidade de São Paulo. Departamento de Doenças Infecciosas. São Paulo. BR
  • Moreira, Regina Célia; Instituto Adolfo Lutz. Centro de Virologia. Laboratório de Hepatites Virais. São Paulo. BR
Rev. Soc. Bras. Med. Trop ; 51(6): 737-741, Nov.-Dec. 2018. graf
Article in English | LILACS | ID: biblio-977103
ABSTRACT
Abstract

INTRODUCTION:

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) have identical transmission routes, explaining the high prevalence of coinfections. The main aim of this study was to detect fluctuations in serological HCV levels in HIV patients.

METHODS:

We analyzed samples of 147 patients who attended an outpatient service that supports HIV/AIDS patients in São Paulo city. We also recruited 22 HCV-monoinfected patients who attended the Instituto Adolfo Lutz Laboratory in São Paulo city, to compare the test results. Serological testing of the blood samples was performed for the detection of HCV antibodies. The samples were then analyzed using real-time PCR for RNA viral quantification and sequencing. RESULTS We found that 13.6% of the study population was coinfected with HIV and HCV. In 20% of coinfected patients, fluctuations in serology results were detected in samples collected during the follow-up. No changes in anti-HCV serological markers were observed in HCV-monoinfected patients. An HCV viral load was detected in 9,5% of the samples collected from HIV patients.

CONCLUSIONS:

Our findings provide important clinical data to public health professionals and highlight the importance of periodic monitoring of HCV/HIV coinfected patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: RNA, Viral / HIV Infections / Hepatitis C / Hepatitis C Antibodies Type of study: Diagnostic study / Risk factors Limits: Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Adolfo Lutz/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: RNA, Viral / HIV Infections / Hepatitis C / Hepatitis C Antibodies Type of study: Diagnostic study / Risk factors Limits: Female / Humans / Male Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Adolfo Lutz/BR / Universidade de São Paulo/BR