Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells
Rev. bras. farmacogn
;
28(6): 654-657, Nov.-Dec. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-977750
ABSTRACT
ABSTRACT About 31 percent of deaths worldwide result from atherosclerotic cardiovascular disease. Hyperlipidemia remains the major risk factor for this disease and therefore, it is necessary to identify antihyperlipidemic compounds for drug development. The crude ethanolic extract of Cryptolepis sanguinolenta (Lindl.) Schltr., Apocynaceae, has demonstrated antihyperlipidemic properties. However, the chemical constituents responsible for this action are unknown. Hence, to identify chemical constituent(s) of C. sanguinolenta with anti-hyperlipidemic effect, five indoloquinoline alkaloids were isolated and evaluated in 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl-indocarbocyanine perchlorate labeled low density lipoprotein uptake assay using HepG2 cells. The minor alkaloid, isocryptolepine, showed strong activity in promoting low lipid lipoprotein uptake by 1.85-fold. Isocryptolepine may, therefore, serve as a lead compound for future studies in the development of novel antihyperlipidemic drugs.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Prognostic study
/
Risk factors
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2018
Type:
Article
/
Project document
Affiliation country:
China
Institution/Affiliation country:
Chinese Academy of Sciences/CN
Similar
MEDLINE
...
LILACS
LIS