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Association between matrix metallopeptidase 9 polymorphism and breast cancer risk / Associação entre o polimorfismo do gene metalopeptidase de matriz 9 e o risco de câncer de mama
Felizi, Rogério Tadeu; Veiga, Melissa Gonzalez; Carelli Filho, Ivo; Souto, Ricardo Peres do; Fernandes, César Eduardo; Oliveira, Emerson.
  • Felizi, Rogério Tadeu; Faculty of Medicine of ABC. Department of Gynecology. Santo André. BR
  • Veiga, Melissa Gonzalez; Faculty of Medicine of ABC. Department of Gynecology. Santo André. BR
  • Carelli Filho, Ivo; Faculty of Medicine of ABC. Department of Gynecology. Santo André. BR
  • Souto, Ricardo Peres do; Faculty of Medicine of ABC. Department of Biochemistry. Santo André. BR
  • Fernandes, César Eduardo; Faculty of Medicine of ABC. Department of Gynecology. Santo André. BR
  • Oliveira, Emerson; Faculty of Medicine of ABC. Department of Gynecology. Santo André. BR
Rev. bras. ginecol. obstet ; 40(10): 620-624, Oct. 2018. tab
Article in English | LILACS | ID: biblio-977784
ABSTRACT
Abstract Objective Epidemiological studies have shown evidence of the effect of genetic variations in the pathogenesis of breast cancer and have suggested a relationship of the disease with genetic polymorphisms. Matrix metallopeptidase 9 (MMP-9) is a collagenase responsible for the degradation of type IV collagen, the major component of the basement membrane, and other essential extra cellular matrix components, being involved in the tumor cell invasion and metastasis. Our objective was to evaluate the relationship between the MMP-9-1562 C/T polymorphism (rs 3918242) and the risk of developing breast cancer. Methods In this case-control study, the frequency of the MMP-9-1562 C/T polymorphism (rs 3918242) was determined in 148 women with breast cancer and 245 women without the disease. The DNA was extracted from plasma samples, and the gene was amplified by polymerase chain reaction (PCR); the presence of the polymorphism was determined using restriction enzymes. Results After adjusting for confounding variables, we found that the polymorphism was not associated with the occurrence of breast cancer (odds ratio [OR] = 1.159, 95% confidence interval [CI] 0.6625-1.997, p = 0.5964). We also found no association with more advanced disease, the presence of hormone receptors, human epidermal growth factor receptor 2 (HER2) overexpression, or rate of tumor cell proliferation. Conclusion We did not observe a relationship between MMP-9-1562 C/T polymorphism (rs 3918242) and the occurrence of breast cancer.
RESUMO
Resumo Objetivo Estudos epidemiológicos vêm demonstrando evidências da influência de variações genéticas na patogênese do câncer de mama, e têm sugerido associação de polimorfismos comuma maior susceptibilidade à doença. A metalopeptidase dematriz 9 (MMP-9) é uma colagenase responsável pela degradação do colágeno tipo IV, omaior componente da membrana basal, e outros componentes essenciais da matriz extra celular, estando envolvido na invasão da célula tumoral emetástase. Nosso objetivo foi avaliar a associação entre o polimorfismo da 1562 C/T (rs 3918242) do gene MMP-9 e o desenvolvimento da neoplasia mamária. Métodos Neste estudo caso-controle, a frequência de polimorfismo 1562 C/T (rs 3918242) do MMP-9 foi determinada em 148 mulheres com câncer de mama e 245 mulheres sem a doença. O DNA foi extraído do plasma e o gene foi amplificado por meio de reação em cadeia da polimerase (RCP). O polimorfismo foi determinado por enzimas de restrição. Resultados O polimorfismo, após o ajuste para variáveis confundidoras, não foi associado coma ocorrência de câncer de mama (razão de possibilidade [RP] = 1,159, intervalo de confiança de 95% [IC95] 0,6625-1,997, p = 0,5964). Também não foi demonstrado associação comestadiamentos mais avançados, presença de receptores hormonais, superexpressão de HER2 e tampouco com a taxa de proliferação celular do tumor. Conclusão Não observamos relação entre o polimorfismo 1562 C/T (rs 3918242) do gene MMP-9 e a ocorrência de câncer de mama.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Matrix Metalloproteinase 9 / Polymorphism, Single Nucleotide Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Female / Humans Language: English Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculty of Medicine of ABC/BR

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Matrix Metalloproteinase 9 / Polymorphism, Single Nucleotide Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Female / Humans Language: English Journal: Rev. bras. ginecol. obstet Journal subject: Gynecology / Obstetrics Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Faculty of Medicine of ABC/BR