Association of angiotensin-converting enzyme insertion/deletion polymorphism with recurrent pregnancy loss: a meta-analysis of 26 case-control studies
Rev. bras. ginecol. obstet
;
40(10): 631-641, Oct. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-977788
ABSTRACT
Abstract Objective Previous studies investigating the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and recurrent pregnancy loss (RPL) risk has provided inconsistent results. The aim of our study was to assess the association between the ACE I/D polymorphism and risk of RPL. Methods All studies published up to January 30, 2018 on the association of ACE I/D polymorphism with RPL were identified by searching the PubMed, Web of Knowledge, and Google scholar databases. Results A total of 26 case-control studies with 3,140 RPL cases and 3,370 controls were included in themeta-analysis. Overall, there was a significant association between ACE I/D polymorphism and RPL risk under the allele model (I versus D odds ratio [OR] = 0.538, 95% confidence interval [CI] = 0.451-0.643, p 0.001), the homozygote model (II versus DD OR = 0.766, 95% CI = 0.598-0.981, p = 0.035) and the recessive model (II versus ID + DD OR = 0.809, 95% CI = 0.658-0.994, p = 0.044). Subgroup analysis by ethnicity showed that there was a significant association between ACE I/D polymorphism and increased risk of RPL in Caucasian and West-Asian populations, but not in East-Asians. When stratified by number of recurrent miscarriages (RMs), a significant association between ACE I/D polymorphism and increased risk of RPL was detected in the group of studies with ≥ 2 RMs, but not in studies with ≥ 3 RMs. Conclusion Themeta-analysis suggests that ACE I/D polymorphism is associated with increased risk of RPL. The ACE I/D polymorphism may be a risk factor for RPL in Caucasian and West-Asian populations, but not in East-Asians.
Full text:
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Index:
LILACS (Americas)
Main subject:
Abortion, Habitual
/
Peptidyl-Dipeptidase A
/
Polymorphism, Single Nucleotide
Type of study:
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Rev. bras. ginecol. obstet
Journal subject:
Gynecology
/
Obstetrics
Year:
2018
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Arak University of Medical Sciences/IR
/
Semnan University of Medical Sciences/IR
/
Shahid Sadoughi University of Medical Sciences/IR
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