Cost effectiveness of the cancer prevention program for carriers of the BRCA1/2 mutation
Rev. saúde pública (Online)
;
52: 94, 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-979019
ABSTRACT
ABSTRACT OBJECTIVE:
To analyze the cost effectiveness of the diagnostic program for the germline mutation in BRCA1/2 genes and of preventative strategies for the relatives of patients diagnosed with ovarian cancer associated with this mutation.METHODS:
The study analyzed the cost effectiveness by developing an analysis of the Markov decision process from the perspective of the National Health System. The strategies compared reflect upon the adoption of genetic testing and preventative strategies for relatives or the usual care currently proposed. The incremental cost-effectiveness ratio was expressed in terms of cost per case avoided. The sensitivity analysis was performed in a univariate and deterministic manner.RESULTS:
The study showed increments for effectiveness and for costs when performing genetic testing and adopting prophylactic measures for family members. The incremental cost-effectiveness ratio was estimated at R$908.58 per case of cancer avoided, a figure considered lower than the study's cost-effectiveness threshold (R$7,543.50).CONCLUSIONS:
The program analyzed should be considered a cost-effective strategy for the national situation. Studies in various other countries have reached similar conclusions. One possible ramification of this research might the need to perform a budgetary-impact analysis of making the program one of the country's health policies.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Ovarian Neoplasms
/
Program Evaluation
/
Germ-Line Mutation
/
Genes, BRCA1
/
Genes, BRCA2
Type of study:
Etiology study
/
Evaluation studies
/
Health economic evaluation
/
Prognostic study
/
Screening study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. saúde pública (Online)
Journal subject:
Sa£de P£blica
Year:
2018
Type:
Article
Affiliation country:
Brazil
/
Netherlands
Institution/Affiliation country:
Universidade de São Paulo/BR
/
University of Groningen/NL
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