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Analysis of the clinical characteristics of perianal fistulising crohn's disease in a single center / Análise das características clínicas da doença de crohn fistulizante perianal em um único centro
Xu, Min-Min; Zhu, Ping; Wang, Hao; Yang, Bo-Lin; Chen, Hong-Jin; Zeng, Li.
  • Xu, Min-Min; Affiliated Hospital. Department of Colorectal Surgery. CN
  • Zhu, Ping; Nanjing University of Chinese Medicine. The First Clinical Medical College. Nanjing. CN
  • Wang, Hao; Affiliated Hospital. Department of Colorectal Surgery. CN
  • Yang, Bo-Lin; Affiliated Hospital. Department of Colorectal Surgery. CN
  • Chen, Hong-Jin; Nanjing University of Chinese Medicine. The First Clinical Medical College. Nanjing. CN
  • Zeng, Li; Nanjing University of Chinese Medicine. The First Clinical Medical College. Nanjing. CN
ABCD (São Paulo, Impr.) ; 32(1): e1420, 2019. tab
Article in English | LILACS | ID: biblio-983669
ABSTRACT
ABSTRACT

Background:

Clinical characteristics are keys to improve identification and treatment of Crohn´s disease (CD) so that large sample analysis is of great value.

Aim:

To explore the clinical characteristics of perianal fistulising CD.

Methods:

Analysis of 139 cases focused on their clinical data.

Results:

The proportion of males and females is 3.31; the mean age is 28.2 years; 47.5% of patients had anal fistula before CD diagnosis. Patients with prior perianal surgery and medication accounted for 64.7% and 74.1% respectively. The L3 type of lesion was present in 49.6% and the B1 and B2 types for 51.8% and 48.2% respectively; complex anal fistula was diagnosed in 90.6%. Symptoms of diarrhea were found in 46% and perianal lesions alone in 29.5% of patients. Abnormal BMI values was present in 44.6%; active CD activity index in 64.7%; and 94.2% had active perianal disease activity index. A proportion of patients manifest abnormal C-reactive protein, erythrocyte sedimentation rate, platelet, hemoglobin and albumin.

Conclusion:

We suggest that patients with anal fistula associated to these clinical features should alert the medical team to the possibility of CD, which should be further investigated through endoscopy and imaging examination of alimentary tract to avoid the damage of anal function by routine anal fistula surgery.
RESUMO
RESUMO Racional As características clínicas são fundamentais para melhorar a identificação e o tratamento da doença de Crohn (DC), de modo que a análise da amostra seja de grande valor.

Objetivo:

Explorar as características clínicas da DC fistulizante perianal.

Métodos:

Análise de 139 casos focados em seus dados clínicos.

Resultados:

A proporção de homens e mulheres foi de 3,3 1; a média de idade de 28,2 anos; 47,5% dos pacientes tiveram fístula anal antes do diagnóstico de DC. Pacientes com cirurgia perianal prévia e medicação representaram 64,7% e 74,1%, respectivamente. O tipo de lesão L3 estava presente em 49,6% e os tipos B1 e B2, em 51,8% e 48,2%, respectivamente; fístula anal complexa foi diagnosticada em 90,6%. Sintomas de diarréia foram encontrados em 46% e lesões perianais isoladas em 29,5% dos pacientes. Valores anormais de IMC estavam presentes em 44,6%; índice de atividade DC ativa em 64,7%; e 94,2% tinham índice de atividade de doença perianal ativo. Proporção significativa de pacientes tinha proteína-C reativa, taxa de sedimenta do eritrócito, plaquetas hemoglobina e albumina anormais.

Conclusão:

Sugere-se que pacientes com fístula anal associada às essas características clínicas alertem a equipe médica para a possibilidade de DC, que deve ser investigada por endoscopia e exame de imagem do trato digestivo para evitar dano na função anal pela operação que rotineiramente é realizada no tratamento da fístula anal.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Crohn Disease / Rectal Fistula Type of study: Diagnostic study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: ABCD (São Paulo, Impr.) Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Affiliated Hospital/CN / Nanjing University of Chinese Medicine/CN

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Full text: Available Index: LILACS (Americas) Main subject: Crohn Disease / Rectal Fistula Type of study: Diagnostic study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: ABCD (São Paulo, Impr.) Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Affiliated Hospital/CN / Nanjing University of Chinese Medicine/CN