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Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
Machado, Francisco Heine Ferreira; Castro Filho, Heladio Feitosa de; Babadopulos, Rodrigo Feitosa de Albuquerque Lima; Rocha, Hermano Alexandre Lima; Rocha, José Lima de Carvalho; Moraes Filho, Manoel Odorico de.
  • Machado, Francisco Heine Ferreira; Universidade Federal do Ceará. Department of Surgery. Fortaleza. BR
  • Castro Filho, Heladio Feitosa de; UFC. Department of Surgery. Fortaleza. BR
  • Babadopulos, Rodrigo Feitosa de Albuquerque Lima; Hospital Geral Dr César Cals de Oliveira. Fortaleza. BR
  • Rocha, Hermano Alexandre Lima; UFC. Community Health Department. Fortaleza. BR
  • Rocha, José Lima de Carvalho; UNICHRISTUS. Fortaleza. BR
  • Moraes Filho, Manoel Odorico de; UFC. Department of Farmacology. Fortaleza. BR
Acta cir. bras ; 34(1): e20190010000009, 2019. tab, graf
Article in English | LILACS | ID: biblio-983686
ABSTRACT
Abstract

Purpose:

To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation.

Methods:

A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during follow-up. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests.

Results:

Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956).

Conclusion:

The results demonstrated that patients who did not use UDCA showed a 24.4-fold greater probability of developing cholelithiasis.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Postoperative Complications / Ursodeoxycholic Acid / Obesity, Morbid / Cholagogues and Choleretics / Gastric Bypass / Gallstones Type of study: Controlled clinical trial / Etiology study / Observational study Limits: Adult / Female / Humans / Male Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Geral Dr César Cals de Oliveira/BR / UFC/BR / UNICHRISTUS/BR / Universidade Federal do Ceará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Postoperative Complications / Ursodeoxycholic Acid / Obesity, Morbid / Cholagogues and Choleretics / Gastric Bypass / Gallstones Type of study: Controlled clinical trial / Etiology study / Observational study Limits: Adult / Female / Humans / Male Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital Geral Dr César Cals de Oliveira/BR / UFC/BR / UNICHRISTUS/BR / Universidade Federal do Ceará/BR