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Association between tumor-infiltrating lymphocytes and sentinel lymph node positivity in thin melanoma
Santos, Fernando De Marco dos; Silva, Felipe Correa da; Pedron, Julia; Furian, Roque Domingos; Fortes, Cristina; Bonamigo, Renan Rangel.
  • Santos, Fernando De Marco dos; Universidade de Caxias do Sul. Department of Oncology. Caxias do Sul. BR
  • Silva, Felipe Correa da; Universidade Federal de Ciências da Saúde de Porto Alegre. Faculdade de Medicina. Porto Alegre. BR
  • Pedron, Julia; Universidade Federal de Ciências da Saúde de Porto Alegre. Faculdade de Medicina. Porto Alegre. BR
  • Furian, Roque Domingos; Santa Casa de Porto Alegre. Laboratory of Pathology. Porto Alegre. BR
  • Fortes, Cristina; Istituto Dermopatico dell'Immacolata. Department of Epidemiology. Rome. IT
  • Bonamigo, Renan Rangel; Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Porto Alegre. BR
An. bras. dermatol ; 94(1): 47-51, Jan.-Feb. 2019. tab
Article in English | LILACS | ID: biblio-983750
Responsible library: BR1.1
ABSTRACT
Abstract

Background:

Sentinel lymph node biopsy in thin invasive primary cutaneous melanoma (up to 1mm thick) is a controversial subject. The presence of tumor-infiltrating lymphocytes could be a factor to be considered in the decision to perform this procedure.

Objective:

To evaluate the association between the presence of tumor-infiltrating lymphocytes and lymph node metastases caused by thin primary cutaneous melanoma.

Methods:

Cross-sectional study with 137 records of thin invasive primary cutaneous melanoma submitted to sentinel lymph node biopsy from 2003 to 2015. The clinical variables considered were age, sex and topography of the lesion. The histopathological variables assessed were tumor-infiltrating lymphocytes, melanoma subtype, Breslow thickness, Clark levels, number of mitoses per mm2, ulceration, regression and satellitosis. Univariate analyzes and logistic regression tests were performed as well the odds ratio and statistical relevance was considered when p <0.05.

Results:

Among the 137 cases of thin primary cutaneous melanoma submitted to sentinel lymph node biopsy, 10 (7.3%) had metastatic involvement. Ulceration on histopathology was positively associated with the presence of metastatic lymph node, with odds ratio =12.8 (2.77-59.4 95% CI, p=0.001). The presence of moderate/marked tumor-infiltrating lymphocytes was shown to be a protective factor for the presence of metastatic lymph node, with OR=0.20 (0.05-0.72 95% CI, p=0.014). The other variables - clinical and histopathological - were not associated with the outcome. Study

limitations:

The relatively small number of positive sentinel lymph node biopsy may explain such an expressive association of ulceration with metastatization.

Conclusions:

In patients with thin invasive primary cutaneous melanoma, few or absent tumor-infiltrating lymphocytes, as well as ulceration, represent independent risk factors for lymph node metastasis.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Lymphocytes, Tumor-Infiltrating / Sentinel Lymph Node / Lymphatic Metastasis / Melanoma Type of study: Prevalence study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2019 Type: Article Affiliation country: Brazil / Italy Institution/Affiliation country: Istituto Dermopatico dell'Immacolata/IT / Santa Casa de Porto Alegre/BR / Universidade Federal de Ciências da Saúde de Porto Alegre/BR / Universidade Federal do Rio Grande do Sul/BR / Universidade de Caxias do Sul/BR

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Full text: Available Index: LILACS (Americas) Main subject: Skin Neoplasms / Lymphocytes, Tumor-Infiltrating / Sentinel Lymph Node / Lymphatic Metastasis / Melanoma Type of study: Prevalence study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: An. bras. dermatol Journal subject: Dermatology Year: 2019 Type: Article Affiliation country: Brazil / Italy Institution/Affiliation country: Istituto Dermopatico dell'Immacolata/IT / Santa Casa de Porto Alegre/BR / Universidade Federal de Ciências da Saúde de Porto Alegre/BR / Universidade Federal do Rio Grande do Sul/BR / Universidade de Caxias do Sul/BR