Thiamine deficiency contributes to synapse and neural circuit defects
Biol. Res
;
51: 35, 2018. graf
Article
in English
| LILACS
| ID: biblio-983939
ABSTRACT
BACKGROUND:
The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer's disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitive impairment. The reduction of thiamine diphosphate may contribute to the dysfunction of synapses and neural circuits, finally leading to cognitive decline.RESULTS:
To demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density. We further detected lowered excitatory neurotransmission and impaired hippocampal long-term potentiation, which are induced by TPK RNAi in vitro. Importantly, via treatment with benfotiamine, Aß induced spines density decrease was considerably ameliorated.CONCLUSIONS:
These results revealed that thiamine deficiency contributed to synaptic dysfunction which strongly related to AD pathogenesis. Our results provide new insights into pathogenesis of synaptic and neuronal dysfunction in AD.
Full text:
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Index:
LILACS (Americas)
Main subject:
Synapses
/
Thiamine Deficiency
/
Thiamine Pyrophosphate
/
Alzheimer Disease
/
Neurons
Limits:
Animals
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Fudan University/CN
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