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The protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats / Efeitos protetores do extrato de uva-do-monte contra a ototoxicidade induzida por cisplatina em ratos
Özdemir, Doğukan; Özgür, Abdulkadir; Kalkan, Yıldıray; Terzi, Suat; Tümkaya, Levent; Yılmaz, Adnan; Çeliker, Metin; Dursun, Engin.
  • Özdemir, Doğukan; University of Health Sciences. Samsun Health Practices and Research Center. Department of Otorhinolaryngology. Samsun. TR
  • Özgür, Abdulkadir; University of Health Sciences. Samsun Health Practices and Research Center. Department of Otorhinolaryngology. Samsun. TR
  • Kalkan, Yıldıray; Recep Tayyip Erdogan University. Medical Faculty. Department of Histology and Embryology. Rize. TR
  • Terzi, Suat; Recep Tayyip Erdogan University. Medical Faculty. Department of Otorhinolaryngology. Rize. TR
  • Tümkaya, Levent; Recep Tayyip Erdogan University. Medical Faculty. Department of Histology and Embryology. Rize. TR
  • Yılmaz, Adnan; Recep Tayyip Erdogan University. Medical Faculty. Department of Biochemistry. Rize. TR
  • Çeliker, Metin; Recep Tayyip Erdogan University. Medical Faculty. Department of Otorhinolaryngology. Rize. TR
  • Dursun, Engin; Recep Tayyip Erdogan University. Medical Faculty. Department of Otorhinolaryngology. Rize. TR
Braz. j. otorhinolaryngol. (Impr.) ; 85(1): 55-62, Jan.-Feb. 2019. tab, graf
Article in English | LILACS | ID: biblio-984047
ABSTRACT
Abstract

Introduction:

Cisplatin is one of the main chemotherapeutic agents used for the treatment of many types of cancer. However, ototoxicity, one of the most serious side effects of cisplatin, restricts its usage.

Objective:

We aimed to investigate the protective effects of whortleberry extract against cisplatin-induced ototoxicity by evaluating hearing and histopathological cochlear damage and by measuring the biochemical parameters affected byoxidative stress.

Methods:

Forty-eight male rats were included in the study after performing Distortion Product Otoacoustic Emission test to confirm that their hearing levels were normal. The rats were randomly divided into six groups the control group, the sham group, and, which received only whortleberry extract, only cisplatin, cisplatin + 100 mg whortleberry extract, cisplatin + 200 mg whortleberry extract, respectively. Audiologic investigation was performed by performing the Distortion Product Otoacoustic Emission test at the beginning and at the eighth day of the study. Cardiac blood samples were collected for biochemical analysis, and the rats were sacrificed to obtain cochlear histopathological specimens on the eighth day.

Results:

The results revealed that whortleberry protects hearing against cisplatin-induced ototoxicity independent of the dose. However, high doses of whortleberry extract are needed to prevent histopathological degeneration and oxidative stress.

Conclusion:

The results obtained in this study show that whortleberry extract has a protective effect against cisplatin-induced ototoxicity.
RESUMO
Resumo

Introdução:

A cisplatina é um dos principais agentes quimioterápicos utilizados para o tratamento de muitos tipos de câncer. No entanto, a ototoxicidade, um dos efeitos colaterais mais graves da cisplatina, restringe seu uso.

Objetivo:

Nosso objetivo foi investigar os efeitos protetores do extrato de uva-do-monte contra a ototoxicidade induzida por cisplatina, avaliar o dano auditivo e histopatológico coclear e medir os parâmetros bioquímicos afetados pelo estresse oxidativo.

Método:

Foram incluídos no estudo 48 ratos machos após teste de emissão otoacústica evocada por produto de distorção para confirmar que seus níveis de audição eram normais. Os ratos foram divididos aleatoriamente em seis grupos o grupo controle, o grupo simulado, o que recebeu apenas extrato de uva-do-monte, o que recebeu apenas cisplatina, o que recebeu cisplatina + 100 mg de extrato de uva-do-monte e o que recebeu cisplatina + 200 mg de extrato de uva-do-monte, respectivamente. A investigação audiológica foi feita através do teste de emissão otoacústica de produto de distorção no início e no oitavo dia do estudo. As amostras de sangue cardíaco foram coletadas para análise bioquímica e os ratos foram sacrificados para obtenção de espécimes histopatológicos cocleares no oitavo dia.

Resultados:

Os resultados revelaram que o extrato de uva-do-monte protege a audição contra a ototoxicidade induzida por cisplatina, independentemente da dose. No entanto, são necessárias doses elevadas do extrato para evitar a degeneração histopatológica e o estresse oxidativo.

Conclusão:

Os resultados obtidos neste estudo mostram que o extrato de uva-do-monte tem um efeito protetor contra a ototoxicidade induzida por cisplatina.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Cisplatin / Cochlea / Protective Agents / Hearing / Anthocyanins / Antineoplastic Agents Type of study: Evaluation studies Limits: Animals Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Recep Tayyip Erdogan University/TR / University of Health Sciences/TR

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Full text: Available Index: LILACS (Americas) Main subject: Cisplatin / Cochlea / Protective Agents / Hearing / Anthocyanins / Antineoplastic Agents Type of study: Evaluation studies Limits: Animals Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Recep Tayyip Erdogan University/TR / University of Health Sciences/TR