ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study
Hematol., Transfus. Cell Ther. (Impr.)
;
40(4): 317-325, Oct.-Dec. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-984501
ABSTRACT
ABSTRACT Background:
Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic B cells, participating in their expansion, differentiation and survival. Chronic lymphocytic leukemia B cells may also drive functional and phenotypic changes of non-malignant T cells. There are few data about the association between memory T cells and prognosis, especially related to ZAP-70, a common reliable surrogate of the gold standard chronic lymphocytic leukemia prognostic markers.Objective:
The aim of this study was to investigate whether the expression of ZAP-70 in chronic lymphocytic leukemia patients is associated with abnormal patterns of the distribution of naïve and memory T cells related to crosstalk between these cells.Methods:
In this cross-sectional, controlled study, patients with chronic lymphocytic leukemia were compared with healthy blood donors regarding the expression of ZAP-70 and the distribution of naïve and memory T cell subsets in peripheral blood as measured by flow cytometry.Results:
ZAP-70 positive patients presented an increased frequency and absolute number of central memory CD4+ T cells, but not CD8+ T cells, compared to ZAP-70 negative patients and age-matched apparently healthy donors.Conclusions:
Because central memory CD4+ T cells are located in lymph nodes and express CD40L, we consider that malignant ZAP-70-positive B cells may receive beneficial signals from central memory CD4+ T cells as they accumulate, which could contribute to more aggressive disease.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Protein-Tyrosine Kinases
/
T-Lymphocytes
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
ZAP-70 Protein-Tyrosine Kinase
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Hematol., Transfus. Cell Ther. (Impr.)
Journal subject:
Hematologia
/
TransfusÆo de Sangue
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital Israelita Albert Einstein/BR
/
Instituto Israelita de Ensino e Pesquisa/BR
/
Universidade de São Paulo/BR
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