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Long term follow up of biomarkers of podocyte damage and renal function in patients with and without preeclampsia / Seguimento de longo prazo com biomarcadores de dano podocitário e função renal em pacientes com e sem pré-eclâmpsia
Franco, Ylbe Palacios de; Velazquez, Karina; Segovia, Natalia; Sandoval, Gladys; Gauto, Estefania; Palacios, Ylbe V. Franco; Palacios, Carlos R Franco.
  • Franco, Ylbe Palacios de; Universidad Católica Nuestra Señora de la Asunción. Facultad de Ciencias de la Salud. Asunción. PY
  • Velazquez, Karina; Instituto de Prevision Social. Departamento de Medicina de Laboratorio. Asuncion. PY
  • Segovia, Natalia; Instituto de Prevision Social. Departamento de Inmunología Clínica. Asuncion. PY
  • Sandoval, Gladys; Instituto de Prevision Social. Departamento de Educación Médica. Asuncion. PY
  • Gauto, Estefania; Universidad Católica Nuestra Señora de la Asunción. Facultad de Ciencias de la Salud. Asunción. PY
  • Palacios, Ylbe V. Franco; South Jersey General Hospital. Department of Obstetrics and Gynecology. Vineland. US
  • Palacios, Carlos R Franco; Rice Memorial Hospital. Department of Nephrology. Affiliated Community Medical Centers. Willmar. US
J. bras. nefrol ; 40(4): 339-343, Out.-Dec. 2018. tab, graf
Article in English | LILACS | ID: biblio-984578
ABSTRACT
ABSTRACT

Introduction:

preeclampsia can be associated with future renal disease.

Objectives:

To measure changes in renal function overtime in patients with preeclampsia.

Methods:

urine and serum samples from eleven patients with preeclampsia and eight patients with a normal pregnancy were obtained during pregnancy, postpartum, and 3 years after delivery. Urine podocalyxin, protein, and serum creatinine were measured.

Results:

after 3 years, there were no significant differences in urinary podocalyxin in patients with or without preeclampsia 4.34 ng/mg [2.69, 8.99] vs. 7.66 ng/mg [2.35, 13], p = 0.77. The same applied to urinary protein excretion 81.5 mg/g [60.6, 105.5] vs. 43.2 mg/g [20.9, 139.3] p = 0.23. Serum creatinine was 0.86 mg/dL [0.7, 0.9] vs. 0.8 mg/dL [0.68, 1] p = 0.74 in those with and without preeclampsia. In normal patients, urinary podocalyxin decreased from 54.4 ng/mg [34.2, 76.9] during pregnancy to 7.66 ng/mg [2.35, 13] three years after pregnancy, p = 0.01. Proteinuria decreased from 123.5 mg/g [65.9, 194.8] to 43.2 mg/g [20.9, 139.3], p = 0.12. In preeclampsia patients, urinary podocalyxin decreased from 97.5 ng/mg [64.9, 318.4] during pregnancy to 37.1 ng/mg within one week post-partum [21.3, 100.4] p = 0.05 and 4.34 ng/mg [2.69, 8.99] three years after, p = 0.003. Proteinuria was 757.2 mg/g [268.4, 5031.7] during pregnancy vs. 757.2 mg/g [288.2, 2917] postpartum, p = 0.09 vs. 81.5 mg/g [60.6, 105.5] three years later, p = 0.01. Two patients still had proteinuria after 3 years.

Conclusions:

in preeclampsia patients, postpartum urinary podocalyxin decreased before proteinuria. After three years, serum creatinine, urinary podocalyxin, and protein tended to normalize, although some patients still had proteinuria.
RESUMO
RESUMO

Introdução:

a pré-eclâmpsia pode estar associada à doença renal no futuro.

Objetivos:

medir mudanças na função renal ao longo do tempo em pacientes com pré-eclâmpsia.

Métodos:

amostras de urina e soro de onze pacientes com pré-eclâmpsia e oito pacientes com gravidez normal foram obtidas durante a gravidez, pós-parto e 3 anos após o parto. Medimos podocalixina na urina, proteína e creatinina sérica.

Resultados:

após 3 anos, não houve diferenças significativas na podocalixina urinária em pacientes com ou sem pré-eclâmpsia 4,34 ng/mg [2,69, 8,99] versus 7,66 ng/mg [2,35, 13], p = 0,77. O mesmo se aplicou à excreção urinária de proteínas 81,5 mg/g [60,6, 105,5] vs. 43,2 mg/g [20,9, 139,3] p = 0,23. A creatinina sérica foi de 0,86 mg/dL [0,7, 0,9] vs. 0,8 mg/dL [0,68, 1] p = 0,74 naqueles com e sem pré-eclâmpsia. Em pacientes normais, a podocalixina urinária diminuiu de 54,4 ng/mg [34,2, 76,9] durante a gestação para 7,66 ng/mg [2,35, 13] três anos após a gravidez, p = 0,01. A proteinúria diminuiu de 123,5 mg/g [65,9, 194,8] para 43,2 mg/g [20,9, 139,3], p = 0,12. Em pacientes com pré-eclâmpsia, a podocalixina urinária diminuiu de 97,5 ng/mg [64,9, 318,4] durante a gravidez para 37,1 ng/mg em uma semana de pós-parto [21,3, 100,4] p = 0,05 e 4,34 ng/mg [2,69, 8,99] três anos depois, p = 0,003. A proteinúria foi de 757,2 mg/g [268.4, 5031.7] durante a gravidez vs. 757,2 mg/g [288.2, 2917] pós-parto, p = 0.09 vs. 81.5 mg/g [60.6, 105.5] três anos depois, p = 0.01. Dois pacientes ainda apresentavam proteinúria após 3 anos.

Conclusões:

em pacientes com pré-eclâmpsia, a podocalixina urinária pós-parto diminuiu antes da proteinúria. Após três anos, a creatinina sérica, a podocalixina urinária e a proteína tenderam a se normalizar, embora alguns pacientes ainda tivessem proteinúria.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pre-Eclampsia / Podocytes / Kidney Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans Language: English Journal: J. bras. nefrol Journal subject: Nephrology Year: 2018 Type: Article Affiliation country: Paraguay / United States Institution/Affiliation country: Instituto de Prevision Social/PY / Rice Memorial Hospital/US / South Jersey General Hospital/US / Universidad Católica Nuestra Señora de la Asunción/PY

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Full text: Available Index: LILACS (Americas) Main subject: Pre-Eclampsia / Podocytes / Kidney Type of study: Observational study / Prognostic study / Risk factors Limits: Adult / Female / Humans Language: English Journal: J. bras. nefrol Journal subject: Nephrology Year: 2018 Type: Article Affiliation country: Paraguay / United States Institution/Affiliation country: Instituto de Prevision Social/PY / Rice Memorial Hospital/US / South Jersey General Hospital/US / Universidad Católica Nuestra Señora de la Asunción/PY