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Improving the reference standard for the diagnosis of canine visceral leishmaniasis: a challenge for current and future tests
Teixeira, Ana Izabel Passarella; Silva, Debora Marcolino; Vital, Tamires; Nitz, Nadjar; de Carvalho, Bruna Caroline; Hecht, Mariana; Oliveira, Diana; Oliveira, Edward; Rabello, Ana; Romero, Gustavo Adolfo Sierra.
  • Teixeira, Ana Izabel Passarella; Universidade de Brasília. Núcleo de Medicina Tropical. Brasília. BR
  • Silva, Debora Marcolino; Universidade de Brasília. Núcleo de Medicina Tropical. Brasília. BR
  • Vital, Tamires; Universidade de Brasília. Núcleo de Medicina Tropical. Brasília. BR
  • Nitz, Nadjar; Universidade de Brasília. Faculdade de Medicina. Laboratório Interdisciplinar de Biociências. Brasília. BR
  • de Carvalho, Bruna Caroline; Universidade de Brasília. Núcleo de Medicina Tropical. Brasília. BR
  • Hecht, Mariana; Universidade de Brasília. Faculdade de Medicina. Laboratório Interdisciplinar de Biociências. Brasília. BR
  • Oliveira, Diana; Grupo de Pesquisas Clínicas e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
  • Oliveira, Edward; Grupo de Pesquisas Clínicas e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
  • Rabello, Ana; Grupo de Pesquisas Clínicas e Políticas Públicas em Doenças Infecciosas e Parasitárias. Belo Horizonte. BR
  • Romero, Gustavo Adolfo Sierra; Universidade de Brasília. Núcleo de Medicina Tropical. Brasília. BR
Mem. Inst. Oswaldo Cruz ; 114: e180452, 2019. tab, graf
Article in English | LILACS | ID: biblio-984755
ABSTRACT
BACKGROUND Studies aimed at validating canine visceral leishmaniasis diagnostic tests present heterogeneous results regarding test accuracy, partly due to divergences in reference standards used and different infection evolution periods in animals. OBJECTIVE This study aimed to evaluate the accuracy of the rapid test-dual path platform (TR-DPP) (Biomanguinhos®), EIE-Leishmaniose-Visceral-Canina-Biomanguinhos (EIE-LVC) (Biomanguinhos®), enzyme-linked immunosorbent assay (ELISA) rK39 (in-house), and the direct agglutination test (DAT-Canis) against a reference standard comprising parasitological and molecular techniques. METHODS A phase II/III validation study was carried out in sample sera from 123 predominantly asymptomatic dogs living in an area endemic for visceral leishmaniasis. FINDINGS Sixty-nine (56.1%) animals were considered infected according to the reference standard. For each test, the sensitivity and specificity, respectively, were as follows TR-DPP, 21.74% [confidence interval (CI)95% 13.64% to 32.82%] and 92.59% (CI95% 82.45% to 97.08%); EIE-LVC, 11.59% (CI95% 5.9% to 21.25%) and 90.74% (CI95% 80.09% to 95.98%); ELISA rK39, 37.68% (CI95% 27.18% to 49.48%) and 83.33% (CI95% 71.26% to 90.98%); and DAT-Canis, 18.84% (CI95% 11.35% to 29.61%) and 96.30% (CI95% 87.46% to 98.98%). CONCLUSION We concluded that improving the sensitivity of serum testing for diagnosing asymptomatic dogs must constitute a priority in the process of developing new diagnostic tests to be used in the visceral leishmaniasis control program in Brazil.
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Full text: Available Index: LILACS (Americas) Main subject: Leishmaniasis, Visceral Type of study: Diagnostic study / Practice guideline Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2019 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Grupo de Pesquisas Clínicas e Políticas Públicas em Doenças Infecciosas e Parasitárias/BR / Universidade de Brasília/BR

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Full text: Available Index: LILACS (Americas) Main subject: Leishmaniasis, Visceral Type of study: Diagnostic study / Practice guideline Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2019 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Grupo de Pesquisas Clínicas e Políticas Públicas em Doenças Infecciosas e Parasitárias/BR / Universidade de Brasília/BR