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Β-Glucan of candida albicans cell wall extract inhibits salmonella typhimurium colonization by potentiating cellular immunity (cd8 + and cd4 + t cells)
Winarsih, Sri; Kosasih, Tomson; Putera, Marvin Anthony; Rahmadhiani, Nayla; Poernomo, Erlien Lindawati; Runtuk, Kresna Septiandy; Oswari, Melissa Valensia.
  • Winarsih, Sri; Universitas Brawijaya. Faculty of Medicine. Pharmacy Study Program. ID
  • Kosasih, Tomson; Universitas Brawijaya. Faculty of Medicine. Pharmacy Study Program. ID
  • Putera, Marvin Anthony; Universitas Brawijaya. Faculty of Medicine. Medicine Study Program. ID
  • Rahmadhiani, Nayla; Universitas Brawijaya. Faculty of Medicine. Medicine Study Program. ID
  • Poernomo, Erlien Lindawati; Universitas Brawijaya. Faculty of Medicine. Pharmacy Study Program. ID
  • Runtuk, Kresna Septiandy; Universitas Brawijaya. Faculty of Medicine. Medicine Study Program. ID
  • Oswari, Melissa Valensia; Universitas Brawijaya. Faculty of Medicine. Medicine Study Program. ID
Rev. Soc. Bras. Med. Trop ; 52: e20180254, 2019. graf
Article in English | LILACS | ID: biblio-985162
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

Antimicrobial resistance has been reported in the drugs used for the treatment of typhoid fever. The immunomodulatory substance β-glucan can be used as an alternative therapy as it potentiates host immunity. The aims of this study are to observe the effect of Candida albicans cell wall (CCW) extract towards host immunity (TCD8+ and TCD4+ cells in spleen, intestinal sIgA) and its capacity to kill Salmonella in the intestine and liver of typhoid fever mice models.

METHODS:

Typhoid fever mice models were created by infecting mice with S. Typhimurium orally. Mice were divided into four groups the Non-Infected, Infected, CCW (infected mice treated with 300 µg CCW extract/mouse once a day), and Ciprofloxacin groups (infected mice treated with 15 mg/kg BW ciprofloxacin twice a day).

RESULTS:

Secretory IgA (sIgA) concentrations of mice in the CCW group remained unchanged. However, their TCD4+ and TCD8+ cells increased substantially compared to those in the Non-Infected group. In the Ciprofloxacin group, sIgA concentrations increased markedly compared to those in the Non-Infected and CCW groups; TCD4+ and TCD8+ cells also increased significantly compared to those in the Infected Group, but not significant compared to those in the CCW group. Colonization of S. Typhimurium in the intestine and liver decreased significantly in the CCW and Ciprofloxacin groups compared to that in the Infected group, with the lowest reduction being found in the Ciprofloxacin group. CONCLUSIONS The inhibition of S. Typhimurium colonization by CCW is associated with the increase in TCD4+ and TCD8+ cells.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Salmonella typhimurium / Typhoid Fever / Candida albicans / Beta-Glucans Limits: Animals Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Indonesia Institution/Affiliation country: Universitas Brawijaya/ID

Full text: Available Index: LILACS (Americas) Main subject: Salmonella typhimurium / Typhoid Fever / Candida albicans / Beta-Glucans Limits: Animals Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2019 Type: Article Affiliation country: Indonesia Institution/Affiliation country: Universitas Brawijaya/ID