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Fatal Disseminated Herpes Simplex in a very premature neonate
Kylat, Ranjit I; Addams, Joel; Sobonya, Richard E.
  • Kylat, Ranjit I; University of Arizona. Department of Pediatrics. Tucson. US
  • Addams, Joel; University of Arizona. Department of Pathology. Tucson. US
  • Sobonya, Richard E; University of Arizona. Department of Pathology. Tucson. US
Autops. Case Rep ; 8(4): e2018050, Oct.-Dec. 2018. ilus
Article in English | LILACS | ID: biblio-986542
ABSTRACT
Herpes Simplex Virus infections (HSV) are ubiquitous. The neonatal HSV infection (NHSV) is rare. The incidence is estimated globally at only 10.3 per 100,000 births, but it can cause devastating disease in premature infants. Both HSV-1 and HSV-2 can be the etiologic agents in this type of vertically transmittted NHSV infection. Here we describe the pathological findings from a complete autopsy of a very low birth weight infant who succumbed to the infection despite early institution of antiviral treatment. We urge more awareness of this disease with continued surveillance; every effort should be taken to make an early diagnosis and thus prevent this devastating disease.
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Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications, Infectious / Herpes Simplex Type of study: Screening study Limits: Female / Humans / Infant, Newborn Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2018 Type: Article Affiliation country: United States Institution/Affiliation country: University of Arizona/US

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Full text: Available Index: LILACS (Americas) Main subject: Pregnancy Complications, Infectious / Herpes Simplex Type of study: Screening study Limits: Female / Humans / Infant, Newborn Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2018 Type: Article Affiliation country: United States Institution/Affiliation country: University of Arizona/US