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Bullous systemic lupus erythematosus ­ a case report
Padrão, Eduardo Messias Hirano; Teixeira, Lucas Faria; Maruta, Celina Wakisaka; Aoki, Valéria; Silva, Aloisio Souza Felipe da; Kim, Elizabeth In Myung; Smelli, Luciana Avena.
  • Padrão, Eduardo Messias Hirano; Universidade de São Paulo. Medical School. Department of Internal Medicine. São Paulo. BR
  • Teixeira, Lucas Faria; Universidade de São Paulo. Medical School. Department of Internal Medicine. São Paulo. BR
  • Maruta, Celina Wakisaka; Universidade de São Paulo. Medical School. Department of Dermatology. São Paulo. BR
  • Aoki, Valéria; Universidade de São Paulo. Medical School. Department of Dermatology. São Paulo. BR
  • Silva, Aloisio Souza Felipe da; Universidade de São Paulo. University Hospital. Pathology. São Paulo. BR
  • Kim, Elizabeth In Myung; Universidade de São Paulo. University Hospital. Department of Internal Medcine. São Paulo. BR
  • Smelli, Luciana Avena; Universidade de São Paulo. Hospital Universitário. Department of Internal Medcine. São Paulo. BR
Autops. Case Rep ; 9(1): e2018069, Jan.-Mar. 2019. ilus
Article in English | LILACS | ID: biblio-987151
ABSTRACT
Skin involvement in systemic lupus erythematosus (SLE) occurs in more than 75% of patients with this condition. Vesicles and blisters in lupus erythematosus (LE) may be present in SLE secondary to interface vacuolar changes in the epidermis, in discoid LE also secondary to vacuolar epidermal changes, and in bullous LE secondary to antibodies anti-collagen VII deposits with neutrophilic aggregates. In addition, blisters can occur due to the association of SLE with other autoimmune blistering diseases (e.g. bullous pemphigoid). BSLE is a rare blistering disease that mainly occurs in females (30­40 years old), and less frequently in children and adolescents. The most common presentation is rapid and widespread development of tense vesicles and bullae over erythematous macules or plaques. Preferential sites are superior trunk, proximal superior limbs, and face (lips) with symmetrical distribution. Mucosal involvement is common on perioral, pharyngeal, laryngeal, and genital areas. The involvement of sun-exposed areas is not mandatory. The lesions usually progress with no scarring, but hypo or hyperchromia may be present. We report an 18-year-old female patient with blistering lesions at admission, who was diagnosed with BSLE. She was initially treated with systemic prednisone and hydroxychloroquine. Her condition evolved with relapsing lesions, which required the introduction of Dapsone. The authors emphasize the relevance of recognizing BSLE­a rare presentation of SLE­which may evolve with marked clinical presentation
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Full text: Available Index: LILACS (Americas) Main subject: Skin Diseases, Vesiculobullous / Lupus Erythematosus, Systemic Limits: Adolescent / Female / Humans Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Skin Diseases, Vesiculobullous / Lupus Erythematosus, Systemic Limits: Adolescent / Female / Humans Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR