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Effects of icariside II on brain tissue oxidative stress and Nrf2/HO-1 expression in rats with cerebral ischemia-reperfusion injury
Li, Yan; Meng, Fanjun.
  • Li, Yan; Shandong University. Jinan City Central Hospital Affiliated. Department of Anesthesiology. CN
  • Meng, Fanjun; Shandong University. Jinan City Central Hospital Affiliated. Department of Anesthesiology. CN
Acta cir. bras ; 34(2): e201900208, 2019. tab, graf
Article in English | LILACS | ID: biblio-989057
ABSTRACT
Abstract

Purpose:

To investigate the effects of icariside II on brain tissue oxidative stress and Nrf2/HO-1 expression in rats with cerebral ischemia-reperfusion injury (CIRI).

Methods:

One hundred SD rats were randomly divided into sham-operated, model, and 5, 10 and 20 mg/kg icariside II groups, 20 rats in each group. The middle cerebral artery occlusion model (ischemia for 2 h followed by reperfusion for 24 h) was established in the later 4 groups. In later 3 groups, at reperfusion beginning, the rats were intragastrically administrated with 5, 10 and 20 mg/kg icariside II, respectively. After 24 h of reperfusion, the neurological severity score, cerebral water content and cerebral infarction volume, brain tissue oxidative stress indexes and Nrf2 and HO-1 protein expressions were determined.

Results:

Compared with model group, in 20 mg/kg icariside II group the neurological severity score, cerebral water content and cerebral infarction volume, brain tissue ROS content and MDA level were significantly decreased (P<0.05), and the brain tissue SOD, GSH-Px and catalase levels and Nrf2 and HO-1 protein levels were significantly increased (P<0.05).

Conclusion:

Icariside II can alleviate the CIRI in rats through reducing brain tissue oxidative stress and improving Nrf2/HO-1 expression.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Flavonoids / Reperfusion Injury / Brain Ischemia / Oxidative Stress / NF-E2-Related Factor 2 Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Shandong University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Flavonoids / Reperfusion Injury / Brain Ischemia / Oxidative Stress / NF-E2-Related Factor 2 Type of study: Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: China Institution/Affiliation country: Shandong University/CN