Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Acta cir. bras
;
34(3): e201900305, 2019. graf
Article
in English
| LILACS
| ID: biblio-989062
ABSTRACT
Abstract Purpose:
To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).Methods:
The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats.Results:
EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue.Conclusion:
This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stomach Neoplasms
/
Plant Extracts
/
Adenocarcinoma
/
Usnea
/
Acetates
/
Antineoplastic Agents, Phytogenic
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2019
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Ataturk University/TR
/
Erzincan Binali Yildirim University/TR
/
Recep Tayyip Erdogan University/TR
/
Selcuk University/TR
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