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Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Mammadov, Renad; Suleyman, Bahadir; Altuner, Durdu; Demirci, Elif; Cetin, Nihal; Yilmaz, Adnan; Baykal, Huseyin; Alpcan, Hilal; Turumtay, Emine Akyuz; Suleyman, Halis.
  • Mammadov, Renad; Erzincan Binali Yildirim University. Faculty of Medicine. Department of Pharmacology. Erzincan. TR
  • Suleyman, Bahadir; Erzincan Binali Yildirim University. Faculty of Medicine. Department of Pharmacology. Erzincan. TR
  • Altuner, Durdu; Erzincan Binali Yildirim University. Faculty of Medicine. Department of Pharmacology. Erzincan. TR
  • Demirci, Elif; Ataturk University. Faculty of Medicine. Department of Pathology. Erzurum. TR
  • Cetin, Nihal; Selcuk University. Faculty of Medicine. Department of Pharmacology. Konya. TR
  • Yilmaz, Adnan; Recep Tayyip Erdogan University. Faculty of Medicine. Department of Biochemistry. Rize. TR
  • Baykal, Huseyin; Recep Tayyip Erdogan University. Pazar Vocational College. Department of Plant and Animal Breeding. Rize. TR
  • Alpcan, Hilal; Erzincan Binali Yildirim University. Faculty of Medicine. Department of Internal Medicine. Erzincan. TR
  • Turumtay, Emine Akyuz; Recep Tayyip Erdogan University. Faculty of Art end Science. Department of Chemistry. Rize. TR
  • Suleyman, Halis; Erzincan Binali Yildirim University. Faculty of Medicine. Department of Pharmacology. Erzincan. TR
Acta cir. bras ; 34(3): e201900305, 2019. graf
Article in English | LILACS | ID: biblio-989062
ABSTRACT
Abstract

Purpose:

To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).

Methods:

The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats.

Results:

EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue.

Conclusion:

This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Stomach Neoplasms / Plant Extracts / Adenocarcinoma / Usnea / Acetates / Antineoplastic Agents, Phytogenic Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ataturk University/TR / Erzincan Binali Yildirim University/TR / Recep Tayyip Erdogan University/TR / Selcuk University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Stomach Neoplasms / Plant Extracts / Adenocarcinoma / Usnea / Acetates / Antineoplastic Agents, Phytogenic Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ataturk University/TR / Erzincan Binali Yildirim University/TR / Recep Tayyip Erdogan University/TR / Selcuk University/TR