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Low levels of dehydroepiandrosterone sulfate are associated with the risk of developing cardiac autonomic dysfunction in elderly subjects
Lemos, Marina de Paiva; Miranda, Munique Tostes; Marocolo, Moacir; Resende, Elisabete Aparecida Mantovani Rodrigues de; Chriguer, Rosângela Soares; Sordi, Carla Cristina de; Barbosa Neto, Octávio.
  • Lemos, Marina de Paiva; Universidade Federal do Triângulo Mineiro. Departamento de Ciências do Esporte. Uberaba. BR
  • Miranda, Munique Tostes; Universidade Federal do Triângulo Mineiro. Departamento de Ciências do Esporte. Uberaba. BR
  • Marocolo, Moacir; Universidade Federal de Juiz de Fora. Departamento de Fisiologia. Juiz de Fora. BR
  • Resende, Elisabete Aparecida Mantovani Rodrigues de; Universidade Federal do Triângulo Mineiro. Departamento de Endocrinologia e Metabolismo. Uberaba. BR
  • Chriguer, Rosângela Soares; Universidade Federal de São Paulo. Departamento de Biociências. Santos. BR
  • Sordi, Carla Cristina de; Universidade Federal do Triângulo Mineiro. Departamento de Endocrinologia e Metabolismo. Uberaba. BR
  • Barbosa Neto, Octávio; Universidade Federal do Triângulo Mineiro. Departamento de Ciências do Esporte. Uberaba. BR
Arch. endocrinol. metab. (Online) ; 63(1): 62-69, Jan.-Feb. 2019. tab, graf
Article in English | LILACS | ID: biblio-989288
ABSTRACT
ABSTRACT

Objective:

To assess the relationships between serum dehydroepiandrosterone sulfate (DHEA-S) levels and heart rate variability (HRV) among different age groups. Subjects and

methods:

Forty-five healthy men were divided into 3 groups young age (YA; 20-39 yrs; n = 15), middle age (MA; 40-59 yrs; n = 15) and old age (OA; ≥ 60 yrs; n = 15). Hemodynamic parameters, linear analyses of HRV and concentrations of cortisol and DHEA-S were measured at rest.

Results:

The OA group presented a higher resting heart rate (84.3 ± 4.6 bpm) than the YA group (72.0 ± 4.4 bpm; p < 0.05). The YA group showed an attenuated variance of HRV (2235.1 ± 417.9 ms2) compared to the MA (1014.3 ± 265.2 ms2; p < 0.05) and OA (896.3 ± 274.1 ms2; p < 0.05) groups, respectively. The parasympathetic modulation of HRV was lower in both the MA (244.2 ± 58.0 ms2) and OA (172.8 ± 37.9 ms2) groups in comparison with the YA group (996.0 ± 255.4 ms2; p < 0.05), while serum DHEA-S levels were significantly lower in both the MA (91.2 ± 19.6 mg/dL) and OA (54.2 ± 17.7 mg/dL) groups compared to the YA group (240.0 ± 50.8 mg/dL; p < 0.05). A positive correlation between lower serum concentrations of DHEA-S and attenuated variance of HRV (r = 0.47, p = 0.031), as well as lower serum concentrations of DHEA-S and decreased parasympathetic modulation of HRV (r = 0.54, p = 0.010), were found.

Conclusion:

The present study demonstrated that the decline of plasma DHEA-S is associated with reduced cardiac autonomic modulation during the aging process.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Autonomic Nervous System Diseases / Aging / Dehydroepiandrosterone Sulfate / Heart Diseases / Heart Rate Type of study: Etiology study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR / Universidade Federal de São Paulo/BR / Universidade Federal do Triângulo Mineiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Autonomic Nervous System Diseases / Aging / Dehydroepiandrosterone Sulfate / Heart Diseases / Heart Rate Type of study: Etiology study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Juiz de Fora/BR / Universidade Federal de São Paulo/BR / Universidade Federal do Triângulo Mineiro/BR