Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study
Clinics
;
74: e739, 2019. tab
Article
in English
| LILACS
| ID: biblio-989646
ABSTRACT
OBJECTIVE:
In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated.METHOD:
DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method.RESULT:
At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study.CONCLUSION:
There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.
Full text:
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Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Osteoporosis, Postmenopausal
/
Spinal Fractures
/
Osteoporotic Fractures
/
Vitamin K Epoxide Reductases
Type of study:
Observational study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2019
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Aksaray University/TR
/
Eskişehir State Hospital/TR
/
Eskisehir Osmangazi University/TR
/
Istanbul Aydin University/TR
/
Kutahya Health Sciences University/TR
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