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Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study
Ozgen, Merih; Cosan, Didem Turgut; Doganer, Fulya; Soyocak, Ahu; Armagan, Onur; Kuzgun, Selen; Aydogan, Ayse Merve; Gunes, Hasan Veysi; Degirmenci, Irfan; Mutlu, Fezan.
  • Ozgen, Merih; Eskisehir Osmangazi University. Faculty of Medicine. Department of Physical Medicine and Rehabilitation. Eskisehir. TR
  • Cosan, Didem Turgut; Eskisehir Osmangazi University. Faculty of Medicine. Department of Medical Biology. Eskisehir. TR
  • Doganer, Fulya; Aksaray University. Faculty of Arts and Sciences. Department of Biotechnology and Molecular Biology. Aksaray. TR
  • Soyocak, Ahu; Istanbul Aydin University. Faculty of Medicine. Department of Medical Biology and Genetics. Istanbul. TR
  • Armagan, Onur; Eskisehir Osmangazi University. Faculty of Medicine. Department of Physical Medicine and Rehabilitation. Eskisehir. TR
  • Kuzgun, Selen; Eskişehir State Hospital. Zübeyde Hanım Campus. Department of Physical Medicine and Rehabilitation. Eskisehir. TR
  • Aydogan, Ayse Merve; Eskisehir Osmangazi University. Faculty of Medicine. Department of Physical Medicine and Rehabilitation. Eskisehir. TR
  • Gunes, Hasan Veysi; Eskisehir Osmangazi University. Faculty of Medicine. Department of Medical Biology. Eskisehir. TR
  • Degirmenci, Irfan; Kutahya Health Sciences University. Department of Medical Biology, Faculty of Medicine. Kutahya. TR
  • Mutlu, Fezan; Eskisehir Osmangazi University. Faculty of Medicine. Department of Biostatistics and Medical Informatics. Eskisehir. TR
Clinics ; 74: e739, 2019. tab
Article in English | LILACS | ID: biblio-989646
ABSTRACT

OBJECTIVE:

In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated.

METHOD:

DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method.

RESULT:

At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study.

CONCLUSION:

There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Osteoporosis, Postmenopausal / Spinal Fractures / Osteoporotic Fractures / Vitamin K Epoxide Reductases Type of study: Observational study / Risk factors Limits: Aged / Female / Humans Country/Region as subject: Asia Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Aksaray University/TR / Eskişehir State Hospital/TR / Eskisehir Osmangazi University/TR / Istanbul Aydin University/TR / Kutahya Health Sciences University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Polymorphism, Genetic / Osteoporosis, Postmenopausal / Spinal Fractures / Osteoporotic Fractures / Vitamin K Epoxide Reductases Type of study: Observational study / Risk factors Limits: Aged / Female / Humans Country/Region as subject: Asia Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Turkey Institution/Affiliation country: Aksaray University/TR / Eskişehir State Hospital/TR / Eskisehir Osmangazi University/TR / Istanbul Aydin University/TR / Kutahya Health Sciences University/TR