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Effects of methanolic extract of Brassica juncea seeds on biochemical parameters and histological integrity of the heart and liver of albino rats / Efectos del extracto metanólico de las semillas de Brassica juncea sobre los parámetros bioquímicos y la integridad histológica del corazón y el hígado de ratas albinas
Azubuike, Nkiruka C; Okwuosa, Chukwugozie N; Maduakor, Uzoamaka C; Onwukwe, Okechukwu S; Onyemelukwe, Anulika O; Ogu, Cornelius O; Ikele, Ikenna T; Oparah, Chioma L; Akande, Adeniyi.
  • Azubuike, Nkiruka C; University of Nigeria. Faculty of Health Sciences and Technology. College of Medicine. NG
  • Okwuosa, Chukwugozie N; University of Nigeria. Faculty of Health Sciences and Technology. College of Medicine. NG
  • Maduakor, Uzoamaka C; University of Nigeria. Faculty of Health Sciences and Technology. College of Medicine. NG
  • Onwukwe, Okechukwu S; University of Nigeria. Faculty of Health Sciences and Technology. College of Medicine. NG
  • Onyemelukwe, Anulika O; University of Nigeria. Faculty of Health Sciences and Technology. College of Medicine. NG
  • Ogu, Cornelius O; University of Nigeria. Faculty of Health Sciences and Technology. College of Medicine. NG
  • Ikele, Ikenna T; University of Nigeria. Faculty of Basic Medical Sciences. College of Medicine. NG
  • Oparah, Chioma L; University of Lagos Teaching Hospital. College of Medicine. NG
  • Akande, Adeniyi; University of Nigeria. Faculty of Health Sciences and Technology. College of Medicine. NG
Int. j. morphol ; 37(1): 237-240, 2019. tab, graf
Article in English | LILACS | ID: biblio-990033
ABSTRACT

SUMMARY:

Brassica juncea (Indian mustard) seeds are consumed in treatment of high blood pressure, headache and prevention of heart disease. The aim of the present study was to investigate the effects of methanol extract of Brassica juncea seeds [BJME] on the heart and liver of adult Albino Wistar rats. A total of 24 albino rats of both sexes were divided into 6 groups [I - VI] of 4 rats per group. Groups I to IV received graded doses of the methanol extract by oral gavage while groups V and VI (controls) received 2 ml/kg body weight of 3 % Tween 80 and water respectively via oral gavage once daily. Treatment lasted for four weeks and the serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were estimated. The animals were sacrificed and the heart and liver tissues were excised for further histological processing for light microscopy. There was significant increase in AST and ALT levels following BJME treatment when compared to the controls. ALP activity did not differ significantly among the treatment and control groups. Histopathological changes consistent with toxic injury were observed in the heart and liver tissues of BJME- treated rats. In conclusion, the results of this study show that sub-acute administration of methanol seed extract of Brassica juncea can exert cardiotoxic and hepatotoxic effects in rats.
RESUMEN
RESUMEN Las semillas de Brassica juncea (mostaza india) se consumen en el tratamiento de la hipertensión arterial, el dolor de cabeza y la prevención de enfermedades del corazón. El objetivo del presente estudio fue investigar los efectos del extracto de metanol de semillas de Brassica juncea [BJME] en el corazón y el hígado de ratas Albino Wistar adultas. Un total de 24 ratas albinas de ambos sexos se dividieron en 6 grupos [I - VI] de 4 ratas por grupo. Los grupos I a IV recibieron dosis del extracto de metanol por sonda oral progresivamente, mientras que los grupos V y VI (control) recibieron 2 ml / kg de peso corporal de 3 % de 80 y agua, respectivamente, por sonda oral una vez al día. El tratamiento duró cuatro semanas y se estimaronlos niveles séricos de aspartato transaminasa (AST), alanina transaminasa (ALT) y fosfatasa alcalina (ALP). Los animales se sacrificaron y fueron analizados los tejidos del corazón y el hígado, para un procesamiento histológico adicional con microscopía óptica. Hubo un aumento significativo en los niveles de AST y ALT después del tratamiento con BJME en comparación con los controles. La actividad de ALP no difirió significativamente entre los grupos de tratamiento y control. Se observaron cambios histopatológicos compatibles con lesiones tóxicas en los tejidos del corazón y el hígado de ratas tratadas con BJME. En conclusión, los resultados de este estudio muestran que la administración subaguda de extracto de semilla de metanol de Brassica juncea puede ejercer efectos cardiotóxicos y hepatotóxicos en ratas.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Methanol / Heart / Liver / Mustard Plant Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2019 Type: Article Affiliation country: Nigeria Institution/Affiliation country: University of Lagos Teaching Hospital/NG / University of Nigeria/NG

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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Methanol / Heart / Liver / Mustard Plant Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2019 Type: Article Affiliation country: Nigeria Institution/Affiliation country: University of Lagos Teaching Hospital/NG / University of Nigeria/NG