Your browser doesn't support javascript.
loading
1-triacontanol cerotate isolated from Marsilea quadrifolia Linn. safeguards hippocampal CA3 neurons and augments special memory deficit in chronic epileptic rats / Cerotato de 1-triacontanol aislado de Marsilea quadrifolia Linn. protege las neuronas CA3 del hipocampo y mejora el déficit de memoria especial en ratas epilépticas crónicas
Snehunsu, Adhikari; Nayak, Satheesha B; Kandwal, Mamta; Piyali, Adhikari; Adiga, Murali; Sahoo, Pabitra; Medabala, T; Raghavenra-Rao, K; Joseph, Alex.
  • Snehunsu, Adhikari; Ministry of Youth Affairs and Sports. Netaji Subhash National Institute of Sports. Department of Physiology. IN
  • Nayak, Satheesha B; Manipal Academy of Higher Education. Melaka Manipal Medical College. Department of Anatomy. Manipal. IN
  • Kandwal, Mamta; Government of Uttarakhand. Ministry of Medical Education. Doon Medical College. IN
  • Piyali, Adhikari; Coorg Institute of Dental Sciences Karnataka. Department of Community Dentistry. IN
  • Adiga, Murali; Manipal Academy of Higher Education. Kasturba Medical College. Department of Physiology. Manipal. IN
  • Sahoo, Pabitra; Medica Superspecialty Hospital. Kolkata. IN
  • Medabala, T; Ministry of Youth Affairs and Sports. Netaji Subhash National Institute of Sports. Department of Physiology. IN
  • Raghavenra-Rao, K; Manipal Academy of Higher Education. Kasturba Medical College. Department of Physiology. Manipal. IN
  • Joseph, Alex; Manipal Academy of Higher Education. Manipal College of Pharmaceutical Science. Department of Pharmaceutical Chemistry. Manipal. IN
Int. j. morphol ; 37(1): 265-272, 2019. graf
Article in English | LILACS | ID: biblio-990037
ABSTRACT

SUMMARY:

Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural components have antiepileptic action and this fact remains scientifically unexplored. This study was designed to check the behavioral and neuro-pathological outcome of 1-Triacontanol cerotate (1TAC), isolated from Marsilea quadrifolia Linn. (MQ) on chronic Pentylenetetrazol (PTZ) kindling model of epilepsy in rats. Two-month-old adult male Wistar rats (n=60) were randomly divided into six groups; Group I (Cage Control), II (Vehicle Control), III (Positive Control), IV (Standard drug treated), V (1TAC 40 mg/kg) & VI (1TAC 80 mg/kg). To induce kindling a 35 mg/kg dose of PTZ was injected i.p. in every 48 hrs for 30 days in Group III to VI. Spatial memory performance was tested using Morris water maze, following which brains were further processed for histopathological investigations. Interestingly, 1TAC was able to minimize the loss of pyramidal cells in hippocampal CA3 region. These cellular changes were behaviorally responded as improved special learning and memory, a better spatial navigation and object place configuration. The current study strongly implicates that 1TAC from MQ has potent neuroprotective role and augments special memory deficit in chronic epileptic rats. The isolated component which attenuates spatial memory performance could be beneficial outcome to retain cognitive blunting in chronic epilepsy.
RESUMEN
RESUMEN Actualmente, muchas personas con epilepsia no cuentan con un control adecuado de las convulsiones, incluso con los mejores medicamentos disponibles. Además, varios antiepilépticos tienen un impacto cognitivo adverso además de efectos secundarios. Por lo tanto, la necesidad de nuevos fármacos antiepilépticos sigue siendo un desafío. Sin embargo, muchos de los componentes naturales tienen acción antiepiléptica y este hecho permanece científicamente inexplorado. Este estudio se diseñó para verificar el resultado conductual y neuro-patológico del cerotato de 1-triacontanol (1TAC), aislado de Marsilea quadrifolia Linn. (MQ) en el modelo de epilepsia en ratas del pentilenetetrazol (PTZ) crónico (PTZ). Ratas Wistar adultas de dos meses de edad (n = 60) se dividieron aleatoriamente en seis grupos; Grupo I (Control de jaula), II (Control de vehículo), III (Control positivo), IV (Medicamento estándar de tratamiento), V (1TAC 40 mg / kg) y VI (1TAC 80 mg / kg). Para inducir la inflamación se inyectó una dosis de 35 mg / kg de PTZ i.p. en cada 48 horas durante 30 días en los grupos III a VI. El rendimiento de la memoria espacial se probó utilizando el laberinto de agua de Morris, después de lo cual se procesaron los cerebros para investigaciones histopatológicas. Curiosamente, 1TAC pudo minimizar la pérdida de células piramidales en la región CA3 del hipocampo. Estos cambios celulares respondieron de manera conductual como una mejora del aprendizaje especial y la memoria, una mejor navegación espacial y la configuración del lugar del objeto. El estudio actual implica fuertemente que 1TAC de MQ tiene un potente papel neuroprotector y mejora el déficit de memoria especial en ratas epilépticas crónicas. El componente aislado que atenúa el rendimiento de la memoria espacial podría ser un resultado beneficioso para retener la reducción cognitiva en la epilepsia crónica.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Marsileaceae / Epilepsy / Fatty Alcohols / CA3 Region, Hippocampal / Spatial Memory Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2019 Type: Article Affiliation country: India Institution/Affiliation country: Coorg Institute of Dental Sciences Karnataka/IN / Government of Uttarakhand/IN / Manipal Academy of Higher Education/IN / Medica Superspecialty Hospital/IN / Ministry of Youth Affairs and Sports/IN

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Marsileaceae / Epilepsy / Fatty Alcohols / CA3 Region, Hippocampal / Spatial Memory Limits: Animals Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2019 Type: Article Affiliation country: India Institution/Affiliation country: Coorg Institute of Dental Sciences Karnataka/IN / Government of Uttarakhand/IN / Manipal Academy of Higher Education/IN / Medica Superspecialty Hospital/IN / Ministry of Youth Affairs and Sports/IN