Your browser doesn't support javascript.
loading
Expression of M30 and M65 in celiac disease. Analytical cross-sectional study
Aksoy, Evrim Kahramanoglu; Simsek, Gülçin Güler; Torgutalp, Murat; Sapmaz, Ferdane Pirinççi; Akpinar, Muhammet Yener; Uzman, Metin; Nazligül, Yasar.
  • Aksoy, Evrim Kahramanoglu; Keçiören Training and Research Hospital. Department of Gastroenterology. Ankara. TR
  • Simsek, Gülçin Güler; Keçiören Training and Research Hospital. Department of Pathology. Ankara. TR
  • Torgutalp, Murat; Ankara University Faculty of Medicine. Department Rheumatology. Ankara. TR
  • Sapmaz, Ferdane Pirinççi; Keçiören Training and Research Hospital. Department of Gastroenterology. Ankara. TR
  • Akpinar, Muhammet Yener; Keçiören Training and Research Hospital. Department of Gastroenterology. Ankara. TR
  • Uzman, Metin; Keçiören Training and Research Hospital. Department of Gastroenterology. Ankara. TR
  • Nazligül, Yasar; Keçiören Training and Research Hospital. Department of Gastroenterology. Ankara. TR
São Paulo med. j ; 136(6): 525-532, Nov.-Dec. 2018. tab, graf
Article in English | LILACS | ID: biblio-991701
ABSTRACT
ABSTRACT

BACKGROUND:

The role of villous atrophy in apoptosis, a distinctive feature of celiac disease, is a matter of controversy. The aim of this study was to determine the apoptosis rate through immunohistochemical staining for M30 and M65 in celiac disease cases. DESIGN AND

SETTING:

Analytical cross-sectional study in a tertiary-level center.

METHODS:

Duodenal biopsies from 28 treatment-naive patients with celiac disease, 16 patients with potential celiac disease, 10 patients with a gluten-free diet and 8 controls were subjected to immunohistochemical staining for the end-apoptotic marker M30 and the total cell death marker M65. H-scores were compared. Several laboratory parameters were recorded concomitantly, and at the one-year follow-up for celiac disease and potential celiac disease patients.

RESULTS:

There was a significant difference in H-score for M30 expression between the celiac disease, potential celiac disease and gluten-free diet groups (P = 0.009). There was no significant difference in H-score for M65 expression. There was a positive correlation between the H-score for M30 expression and the anti-tissue transglutaminase immunoglobulin A (anti-tTgIgA) and anti-tissue transglutaminase immunoglobulin G (anti-tTgIgG) levels (R = 0.285, P = 0.036; and R = 0.307, P = 0.024, respectively); and between the H-score for M65 expression and the anti-tTgIgA and anti-tTgIgG levels (R = 0.265, P = 0.053; and R=0.314, P = 0.021, respectively). There was no difference between celiac disease and potential celiac disease patients regarding the laboratory parameters selected.

CONCLUSION:

The rates of apoptosis and nutritional deficiencies in patients with potential celiac disease were similar to those in patients with celiac disease.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Celiac Disease / Apoptosis / Caspases / Keratin-18 Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara University Faculty of Medicine/TR / Keçiören Training and Research Hospital/TR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Celiac Disease / Apoptosis / Caspases / Keratin-18 Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2018 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara University Faculty of Medicine/TR / Keçiören Training and Research Hospital/TR