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Fatal necrotizing Candida esophagitis in a patient with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis
Piubelli, Mario Luiz Marques; Silva, Aloisio Felipe; Kanegae, Marcia Yoshie; Campos, Fernando Peixoto Ferraz de.
  • Piubelli, Mario Luiz Marques; Universidade de São Paulo. Faculty of Medicine. Department of Pathology. São Paulo. BR
  • Silva, Aloisio Felipe; Universidade de São Paulo. Hospital Universitário. Anatomic Pathology Service. São Paulo. BR
  • Kanegae, Marcia Yoshie; Universidade de São Paulo. Hospital Universitário. Internal Medicine Division. São Paulo. BR
  • Campos, Fernando Peixoto Ferraz de; Universidade de São Paulo. Hospital Universitário. Internal Medicine Division. São Paulo. BR
Autops. Case Rep ; 9(2): e2018070, Abr.-Jun. 2019. ilus
Article in English | LILACS | ID: biblio-994653
ABSTRACT
Esophageal infection by Candida spp. is a common opportunistic entity in immunocompromised hosts; however, systemic fungal dissemination due to perforation or transmural necrosis, also known as necrotizing Candida esophagitis (NCE), is rare. We report the case of a 61-year-old male patient with diagnosed ankylosing spondylitis, severe arteriosclerosis, and vasculitis under immunosuppressive therapy who presented NCE with fungal and bacterial septicemia diagnosed at autopsy. Necrotizing esophagitis is a rare manifestation of Candida infection, which may be a final complication in severely ill patients. Unfortunately, it may be underdiagnosed, and we call attention to this devastating complication in patients with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis.
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Full text: Available Index: LILACS (Americas) Main subject: Esophagitis / Candidiasis, Invasive / Mycoses / Necrosis Limits: Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Esophagitis / Candidiasis, Invasive / Mycoses / Necrosis Limits: Humans / Male Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR