Oral Candidal Carriage Among Patients with Oral Potential Malignant Disorders: A Case-Control Study
Pesqui. bras. odontopediatria clín. integr
;
19(1): 4802, 01 Fevereiro 2019. tab
Article
in English
| LILACS, BBO
| ID: biblio-998255
ABSTRACT
Objective:
To determine the prevalence of Candida species in the saliva of patients with clinically suspected oral potentially malignant disorders (OPMD) and healthy cohorts. Material andMethods:
Unstimulated saliva was collected from patients with OPMD (n=100) and age and sex matched healthy subjects (n=170). The samples were inoculated onto Sabouraud Dextrose Agar and incubated for a week. The colonies of the isolates were enumerated using a colony counter. The isolates were identified using standard phenotypic methods. The significance of oral candidal carriage was calculated using Independent T test. Odds and Risk ratio was calculated using Pearson's Chi-square test.Results:
Oral candida carriage was present in 51% of patients with OPMD while healthy cohorts had a prevalence of 20.6%. A good statistical significance was observed for the prevalence of oral candidal carriage for patients with OPMD in comparison to healthy cohorts (p=0.013). Significant Odds and risk ratio was observed for the prevalence of Candida species among OPMD. Majority of the isolates in both groups were C. albicans. Colony forming units were high among patients with OPMD.Conclusion:
A significant association of oral candidal carriage to oral potentially malignant disorders in comparison to healthy cohorts was observed. Candidal species may be potent risk factor for transition of OPMD to oral Squamous Cell Carcinoma.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Phenotype
/
Candidiasis, Oral
/
Leukoplakia, Oral
/
Mouth Neoplasms
/
Case-Control Studies
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Pesqui. bras. odontopediatria clín. integr
Journal subject:
Dentistry
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS