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Structural Assessment of Chemical Constituent of Sidaguri (Sida rhombifolia Linn) and Its Ability to Inhibit Cyclooxygenase
Tanumihadja, Maria; Mattulada, Indrya K; Natsir, Nurhayaty; Subehan, Subehan; Mandey, Fredryk; Muslimin, Lukman.
Affiliation
  • Tanumihadja, Maria; s.af
  • Mattulada, Indrya K; s.af
  • Natsir, Nurhayaty; s.af
  • Subehan, Subehan; s.af
  • Mandey, Fredryk; s.af
  • Muslimin, Lukman; s.af
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4773, 01 Fevereiro 2019. tab, graf
Article in En | LILACS, BBO | ID: biblio-998267
Responsible library: BR1264.1
ABSTRACT

Objective:

To elicit the structure of isolated compounds from roots of sidaguri (Sida rhombifolia Linn). Material and

Methods:

Several organic standard protocols were involved, including extraction, fractionation, and phytochemical testing. Further spectroscopy methods, FTIR and 1HNMR, were used to determine the predicted structure of molecules, while their ability to inhibit cyclooxygenase (COX 1 and 2) were tested using in vitro method.

Results:

Overall assessments showed that the structure of the sidaguri is a long chain aliphatic carboxylic acid and identified as Z-3, 6, 6 trimethylhept-2-en-1-ol (T12) and nonanoic (T13). Both isolates significantly inhibit COX-1 and COX-2 non-selectively (the COX-1/COX-2 ratio for T12 was 0.91 and 0.82; while COX-1/COX-2 ratio for T13 was 0.89 and 0.87 at concentrations of 0.05 and 0.025 µg/mL respectively).

Conclusion:

The active compounds of Sidaguri have antiinflammatory effect by inhibiting COX non-selectively.
Subject(s)
Key words

Full text: 1 Index: LILACS Main subject: Spectrum Analysis / Cyclooxygenase 1 / Cyclooxygenase 2 / Anti-Inflammatory Agents Country/Region as subject: Asia Language: En Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: ODONTOLOGIA Year: 2019 Type: Article

Full text: 1 Index: LILACS Main subject: Spectrum Analysis / Cyclooxygenase 1 / Cyclooxygenase 2 / Anti-Inflammatory Agents Country/Region as subject: Asia Language: En Journal: Pesqui. bras. odontopediatria clín. integr Journal subject: ODONTOLOGIA Year: 2019 Type: Article