[Efficacy of Clotrimazole, Nystatin and Povidone Iodine in traetment of patients with vaginal candidiasis]

ABSTRACT

Vaginal candidiasis is one of the most frequent infections of the female genital tract in different countries. The goal of this study was to evaluate the efficacy of clotrimazile, nystatin and povidone iodine [betadine] in treatment of vaginal candidiasis in patients referred to gynecologic clinics of Mashhad. This is a clinical trial study on wemon referring to gynecologic clinics in Ghaem, Imam Reza, Imam Zaman and Ali - e - bn - e - Abi taleb centers, for vaginal discharge. Vaginal candidiasis was confirmed by direct fresh smear, Papanicolao staining, gram staining and culture. Among 300 cases, considering inclusion and exclusion criteria, 130 pateints suffering from vaginal candidiasis were selected. Each received either vaginal tablets of clotrimazole, nystatin or vaginal gel of betadine randomly. Among 300 patients suffering from vaginitis symptoms, candidiasis was confirmed only in 43% of the cases, most of them between 25-35 years old. Clotrimazole was more effective than betadine clinically. There was no significant difference between nystatin, clotrimazole or betadine in treatment of patients. Betadine side effects were more prominant compared to clotrimazole and nystatine. It is concluded that compared to betadine, clotrimazole and nystatin are safer in treatment of vaginal candidiasis and because of shorter duration of treatment, usage of clotrimazole is more reasonable in treatment of vaginal candidiasis compared to nystatin and betadine