Effect of tamaron [organophosphorus] on fertility with reference to steroids, thyrotorophic and thyroid hormones secretion in female rats

ABSTRACT

Mature female rats were treated with methamidophos [Tamaron of Bayer Co., West Germany] daily through drinking water at a rate of 100 ppm daily for 9 [short-term] and 45 [long-term] days. The results revealed that methamidophos reduced the fertility in rats where it led to death and resorption of the embryos. Methamidophos led to a decrease in blood estradiol and progesterone in short-term treated rats. While, in long-term treated rats, there was an increase in estradiol and a decrease in progesterone concentrations. Treatment of rats with methamidophos did not alter thyrotrophic hormone [TSH] concentration, while thyroxine [T4] and triiodothyronine [T3] concentrations were decreased