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Palliative treatment of intractable hematuria in context of advanced bladder cancer a systematic review
Urology Journal. 2009; 6 (3): 149-156
in English | IMEMR | ID: emr-100198
ABSTRACT
In a patient with bladder urothelial cancer that is not suitable for or does not choose curative treatment, intractable hematuria is a disastrous condition. In this article, we tried to review the literature and extract a stepwise approach for palliative treatment of hematuria in these patients. The MEDLINE was searched with the help of the Medical Subject Headings system using different combinations of terms urinary bladder neoplasm, hematuria, carboprost, cyclophosphamide, cystitis, alum, and hyperbaric oxygenation. The articles were separately reviewed by the two authors and verified by each other. Eventually, a decision tree was developed for management of gross hematuria in patients with bladder cancer. Although, there was not any reported randomized controlled trial or prospectively designed study, the available case series were rather expressive to draw out a logical approach. Formalin has a grave adverse effect profile and is recommended only in special circumstances. For management of each case of gross hematuria in bladder cancer, the etiology of bleeding is the most important determinant. Hematuria in the context of advanced bladder neoplasms can now be effectively treated with fewer side effects using all available modalities in a logical holistic approach. We proposed a decision tree for management of hematuria in this context. However, regarding lack of well-designed trials, a treatment method should be based on individualized scenarios and clinical experience, bringing into account the patient's preferences
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Index: IMEMR (Eastern Mediterranean) Main subject: Palliative Care / Tromethamine / Urinary Diversion / Administration, Intravesical / Carboprost / Cystectomy / Cyclophosphamide / Alum Compounds / Formaldehyde / Hyperbaric Oxygenation Type of study: Controlled clinical trial / Systematic reviews Limits: Humans Language: English Journal: Urol. J. Year: 2009

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Index: IMEMR (Eastern Mediterranean) Main subject: Palliative Care / Tromethamine / Urinary Diversion / Administration, Intravesical / Carboprost / Cystectomy / Cyclophosphamide / Alum Compounds / Formaldehyde / Hyperbaric Oxygenation Type of study: Controlled clinical trial / Systematic reviews Limits: Humans Language: English Journal: Urol. J. Year: 2009