Prevalence of human T-cell leukemia virus [HTL V-I] in acute lymphatic leukemia and lymphomas in Alexandria

ABSTRACT

The aim of this study was to find the incidence of human T. Cell leukemia virus [HTLV-I] in acute lymphatic leukemia and lymphomas in Alexandria. 100 cases of acute lymphatic leukemia and lymphoma attended the Main University Hospital, out patient clinics and internal medicine department-150 Control of other types of leukemias, cancer and normal subjects attending also the out patient clinics and internal medicine department. The patients and controls were subjected to the following Clinical examination, White cell count total and differential, Bone marrow Aspiration, Lactic acid dehydrogenase enzymens, Serum calcium, Erythrocytic Sedmentation Rate [E.S.R.], C-reactive protein [C.R.F.], Anti HTLV-1 antibodies using SERODI-HTLV-1 [passive particle agglutination test manufactured by FUJIREBIO Inc. Tokyo-Japan]. HTLV-I Ab was positive in 14% in cases of acute lymphatic leukemia and lymphoma. While, it was positive in the control group compared to Normal subjects and other types of leukemia and cancer [3.3%]. It was found that HTLV-1 virus in acute lymphatic leukemia is less than in other endemic areas. Trials for immunization are urgent. Blood blanks examination for the virus is essential, where it is transmitted by 1] blood 2] mother to child [breast feeding] 15 and transpiacental, 3] Sexually transmitted disease [STD]