Studies of some Egyptian medicinal plants as natural wealth in regression of hepatocellular carcinoma [HCC]
Egyptian Pharmaceutical Journal [National Research Center]. 2008; 7 (2): 201-216
in English
| IMEMR
| ID: emr-100909
ABSTRACT
The present investigation was designed to valuate the antiangiogenic efficacy of some local medicinal plants against liver cancer induced by diethylnitrosamine [DEN] methanolic extracts of cupressus sempervirens, chelidonium majus and tropaeolum majus were used in this study. Vascular endothelial growth factor [VEGF], alpha-Feto-protein [AFP], ferritin, alanine transaminase [ALT], aspartate transaminase [AST], Alkaline phosphatase [ALP], superoxide dismutase [SOD] and Glutathione peroxidase [GPx] were determined in blood while Nitric oxide [NO] was determined in liver tissue homogenate. Furthermore histopathological investigations ere done. The results showed that the treatment with methanolic extracts of all selected plants led to a significant reduction in the level of all the desired biochemical parameters, while the administration of cupressus sempervirens only improved the histopathological pictures of liver architecture. These results suggest a beneficial effect of these plant extracts against experimentally-induced hepatocellular carcinoma and the possible mechanism of the protective effects may be partly due to the antioxidant activity of these plants
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Aspartate Aminotransferases
/
Alpha-Fetoproteins
/
Carcinoma, Hepatocellular
/
Angiogenesis Inhibitors
/
Chelidonium
/
Cupressus
/
Tropaeolum
/
Vascular Endothelial Growth Factor A
/
Alanine Transaminase
/
Liver
Language:
English
Journal:
Egypt. Pharm. J. [NRC]
Year:
2008
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