Comparison between cephalothin and ampicillin + gentamicin in treatment of pyelonephritis in pregnancy

ABSTRACT

Urinary tract infection is a common problem in pregnancy and its complications affect both pregnant woman and her fetus. Different treatment strategies have been suggested and some of them are less safe. This study compared the effectiveness of cephalothin treatment with ampicillin + gentamycin protocol. Sixty pregnant patients with pylonephritis in Imam Khomeini and Razi hospitals in Ahwaz were randomized in two groups of 30 patients, one with cephalothin only treatment and the other with ampicillin+gentamycin. Both groups were compared in term of duration of fever, CVA tenderness, symptoms and length of stay in hospital. Cephalothin only group had less duration of fever, approximately eleven hours, which was statisticaly significant. Length of stay and symptoms' relief were also less in cephalothin only group but it had no statistical significance. Cephalothin is a safe and effective remedy in the treatment of pyelonephritis in pregnancy and may be used as the first choice treatment even in severely ill patients