[Hypoglycemic effects of Achillea Wilhelmsii in normal and streptozotocin induced diabetic rats]

ABSTRACT

Diabetes mellitus is a syndrome, initially characterized by a loss of glucose homeostasis resulting from defects in Insulin secretion, insulin action both is resulting in impaired metabolism of glucose and other energy yielding fuels as lipids and protein. Several medicinal herbs have been described with hypoglycemic effects. These include Allium Sativum, Trigonella Foenum, Marus nigra, Ocimum Sanctum, and Astragalus Ovinus. The main purpose of the present study was to determine the effect of Achillea Wilhelmsii C. Koch on blood glucose levels of diabetic rats induced by stereptozotocine [STZ]. In this experimental research, forty-eight male Wistar rats were divided into two groups non-diabetic [normal] and STZ-induced diabetic mice. Each group was further divided into four groups control [induced by normal saline] and treatment received 100, 200 and 300 mg/kg for one month. The blood glucose level was measured and Data were analyzed by t- test and ANOVA. At the end of first month, significant decrease was observed in blood glucose level in diabetic rats which received 100 mg/kg [p<0/001], 200 mg/kg [p<0/01], 300 mg/kg [p<0/001] of aqueous alcoholic extract of Achillea Wilhelmsii c. Koch in comparison with control groups. The extract had not have any significant effects on the blood glucose level of normal groups except in those which received 300mg/kg of the extract. The results of this study showed that aqueous-alcoholic extract of Achillea Wilhelmsii C. Koch have a significant effect on reducing the blood glucose level of diabetic rats