Construction of a dose- response curve by induction of premature chromosome condensation for biological dosimetry

ABSTRACT

Premature Chromosome Condensation [PCC] appears to have a possible utility for biological dosimetry purposes. The PCC technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. For this purpose, human blood samples were exposed in vitro to [60] Co up to 10 Gy and the PCC technique was performed immediately after irradiation. Analysis of excess PCC fragments distribution showed an over dispersion and the dose-effect relationship was best characterized by linear regression