New Egyptian Journal of Medicine [The]. 2008; 38 (2): 83-89
in English
| IMEMR
| ID: emr-101567
ABSTRACT
In this study the availability of murine anti-interleukin-4 [anti IL-4] and anti-interleukin- 13[anti-Il- 13] monoclonal antibodies [mAbs] permited the intimate study of the direct role of IL-13 in a type -2-cytokine mediated infection. The present study demonstrates that blocking of IL-13 from the Th -2 response to Schistosoma mansoni infection is beneficial to host survival. This enhanced prognosis correlates with a reduction in hepatic collagen deposition and indicates the role for IL-13 in the development of hepatic fibrosis. In contrast, the study has also showed that blocking of IL-4 results in very high mortality characterized by a breakdown in intestinal integrity, indicating that IL-4- is a protective cytokine in schistosome infection. The combined blocking of both IL-4 and IL-13 demonstrates that the positive effects resulting from the ablation of IL- 13 were over-ridden by the detrimental pathology resulting from IL-4 blocking. In addition, combined cytokine blocking resulted in a condition that was considerably more severe than that observed in the IL-4 blocking group. These results indicate the potential benefits of anti- IL-13 as an antifibrogenic cytokine, but also show the dangers of blocking both IL-13 and IL-4 concurrently
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Proline
/
Fluorescent Antibody Technique
/
Models, Animal
/
Granuloma
/
Histology
/
Hydroxyproline
/
Immunotherapy
/
Liver
/
Liver Cirrhosis
/
Mice
Limits:
Animals
Language:
English
Journal:
New Egypt. J. Med.
Year:
2008
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