Quality of life of patients with oral and pharyngeal malignancies

ABSTRACT

The target population was cases of oral and pharyngeal cancer in Alexandria and El Behira regions. Data were collected through all accessible archives. Data about quality of life [QoL] were collected through interviewing 171 subjects using the Arabic version of "Functional Living Interview Questionnaire for Cancer" [FLIC]. It consists of 22 items translated into Arabic language, and was checked for reliability and validity. Only 12 questions were found suitable for use after testing the questionnaire. Responses are coded on a 7 point Likert scale. Questions included pain, psychic stress, and ability to work and do household activities. The initial scale's structure identified a two-factor model functional including 6 questions, and psychological including 6 questions. The grand total score was calculated as the sum of responses to the 12 items. The total score of the scale range is 12 to 84 points. The median was used for demarcation between what was considered as "good" response, and what was considered as "poor" QoL. Quality of life displayed higher "good" frequencies among those 30-60 years old. Males, and rural cases expressed better QoL than females and urban. Married were of better QoL compared to single patients. The educated showed higher frequency of "good" compared to un-educated. Employees and professionals reported better QoL. Stage categories showed significant indirect correlation with QoL scores. The best QoL according to total or psychological mean scores was recorded for pharyngeal-otherwise [pharyngeal of a mysterious origin] or lip cases, while the worst were for the floor of the mouth. Lip cases showed the best QoL scores through the functional domain. According to treatment; surgery showed the best QoL, while chemotherapy showed the worst. When it came to chronic irradiation complications; those without complications expressed the best QoL. All those treatment complications showed significant associations with dichotomous leveling of QoL. Logistic regression showed that stage, late surgical complications, and response to treatment were the most important predictors of QoL